Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?

Frontiers in Physiology
Alyssa W GoldmanBrian Berman

Abstract

Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health.

References

Mar 20, 2002·Health Affairs·J Michael McGinnisJames R Knickman
Oct 25, 2002·Pflügers Archiv : European journal of physiology·Peter HunterDenis Noble
Oct 26, 2002·Science·Zoltán N Oltvai, Albert-László Barabási
Nov 15, 2002·Nature·Timothy G Buchman
Dec 20, 2002·Nature·Carl Nathan
Dec 20, 2002·Nature·Peter Libby
Oct 28, 2003·Diabetes Care·David M Eddy, Leonard Schlessinger
Mar 17, 2004·BMC Complementary and Alternative Medicine·Carol M BaldwinIris R Bell
Nov 3, 2004·Nature Reviews. Genetics·Hiroaki Kitano
Nov 25, 2004·Diabetes·Hiroaki KitanoMasaaki Muramatsu
Apr 6, 2005·Trends in Pharmacological Sciences·Péter CsermelySándor Pongor
May 10, 2006·PLoS Medicine·Andrew C AhnRussell S Phillips
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·M E J Newman
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Jan 2, 2007·Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques·Hiroaki Kitano
Feb 3, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanJohn L Wallace
Jun 30, 2007·Nature Clinical Practice. Rheumatology·Dirk FoellJohannes Roth
Jul 13, 2007·Molecular Systems Biology·Joseph LoscalzoAlbert-Laszlo Barabasi
Jul 20, 2007·Biochemical Society Transactions·D J Buttle
Sep 21, 2007·Molecular Systems Biology·Hiroaki Kitano
Dec 14, 2007·Annual Review of Genetics·Jason Pellettieri, Alejandro Sánchez Alvarado
Jan 25, 2008·The European Respiratory Journal·J VestboUNKNOWN ECLIPSE investigators
Mar 11, 2009·Annals of Family Medicine·Kurt C Stange
Mar 25, 2009·Molecular Systems Biology·Daehee HwangLeroy E Hood
May 23, 2009·Health Research Policy and Systems·Jonathan M KaganWilliam M K Trochim
May 28, 2009·Hormones and Behavior·L Michael RomeroNicole E Cyr
Oct 7, 2009·Genome Medicine·Gábor I SimkóPeter Csermely
Oct 23, 2009·British Journal of Pharmacology·Mauro Perretti, Jesmond Dalli
Nov 19, 2009·The Journal of Pathology·Janine T Erler, Rune Linding
Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Alexander HänselRoland von Känel
Jan 23, 2010·Nature Reviews. Cancer·Zachary A KnightKevan M Shokat
Mar 23, 2010·Cell·Carl Nathan, Aihao Ding
May 4, 2010·Lancet·Euan A AshleyRuss B Altman
Nov 9, 2010·Advances in Immunology·Annabel F ValledorAntonio Celada
Dec 15, 2010·Mucosal Immunology·P J Sansonetti
Dec 18, 2010·Nature Reviews. Genetics·Albert-László BarabásiJoseph Loscalzo
Feb 22, 2011·Immunology Letters·Christopher D Buckley
Mar 16, 2011·Mutation Research·Alton EtheridgeKai Wang

❮ Previous
Next ❯

Citations

Mar 15, 2019·Critical Care : the Official Journal of the Critical Care Forum·Toshifumi AsadaNaoto Morimura
Jun 3, 2021·International Journal of Molecular Sciences·Massimo FioranelliLinda Cota
Jul 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lauren CurryJana Sawynok
Aug 25, 2021·Integrative and Comparative Biology·Erica CrespiJared V Goldstone
Nov 20, 2021·Homeopathy : the Journal of the Faculty of Homeopathy·Raj Kumar ManchandaRobbert van Haselen

❮ Previous
Next ❯

Software Mentioned

BrSM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Emergency Medicine Australasia : EMA
Aled Williams
Annals of Biomedical Engineering
Shannon E Telesco, Ravi Radhakrishnan
Journal/ Indiana Dental Association
H W Gilmore
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
Xiao Liu, Luo-sheng Tang
© 2021 Meta ULC. All rights reserved