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Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol

Journal of Pharmaceutical Sciences

Feb 1, 2006

David Ilardia-AranaAnette Müllertz

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Abstract

Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because...read more

Mentioned in this Paper

Soluble
Oleic Acids
Vesicle (Morphologic Abnormality)
Intestines
Vesicle
Estradiol, (16 alpha,17 beta)-Isomer
Estradiol Measurement
Glycine Cholate
Lecithinum, lecithin, Homeopathic preparation
Ampholytes
Paper Details
References
  • References6
  • Citations19
12

Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol

Journal of Pharmaceutical Sciences

Feb 1, 2006

David Ilardia-AranaAnette Müllertz

PMID: 16374874

DOI: 10.1002/jps.20494

Abstract

Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because...read more

Mentioned in this Paper

Soluble
Oleic Acids
Vesicle (Morphologic Abnormality)
Intestines
Vesicle

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Paper Details
References
  • References6
  • Citations19
12

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