Bioresorbable Microspheres with Surface-Loaded Nanosilver and Apatite as Dual-Functional Injectable Cell Carriers for Bone Regeneration

Macromolecular Rapid Communications
Pengfei WeiXiaoping Yang

Abstract

Bone defect repair, especially in terms of infection, remains a big challenge in clinical therapy. To meet clinical requirements, the dual-functional strategy including antibacterial activity and strong osteogenesis effect is a promising approach in bone tissue engineering. In the present study, bioresorbable porous-structured microspheres are fabricated from amphiphilic block copolymer composed of poly(l-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres are loaded with nanosilver via reduction of silver nitrate and apatite via biomineralization in sequence. The resulting composite microspheres are systematically characterized by in vitro coculturing with rat bone mesenchymal stromal cells and Staphylococcus aureus to evaluate cytotoxicity and antibacterial activity. In vivo evaluation is carried out by filling the composite microspheres into infected cranial defects in a rat model. The primary results indicate that the dual-purpose microspheres have the capacity to defeat infection while promoting bone regeneration.

References

Sep 28, 2007·Journal of Biomedical Materials Research. Part a·Sun-Woong KangByung-Soo Kim
Feb 5, 2009·Journal of Biomaterials Science. Polymer Edition·Sun-Woong KangByung-Soo Kim
Mar 27, 2010·Journal of Biomaterials Science. Polymer Edition·Tae-Jin LeeByung-Soo Kim
Dec 7, 2010·Colloids and Surfaces. B, Biointerfaces·Xudong ShiZhihua Gan
Mar 1, 2011·Current Opinion in Biotechnology·Manitha B NairF Kurtis Kasper
Apr 2, 2011·Acta Biomaterialia·P Habibovic, J E Barralet
Feb 13, 2013·Journal of Biomedical Materials Research. Part a·Michael B DreifkeAmbalangodage C Jayasuriya
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Syafiqah SaidinDiego Mantovani
Nov 19, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ke DuZhihua Gan
Mar 13, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·S Connor DennisCory J Berkland
Mar 22, 2014·ACS Nano·Meghan K DriscollWolfgang Losert
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Chengjiao WuBo Peng
Aug 19, 2015·Bioconjugate Chemistry·Samad AhadianAli Khademhosseini
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Hazal AydogduAysen Tezcaner
May 28, 2016·Nanomedicine·Zhanpeng ZhangPeter X Ma
Oct 21, 2016·Tissue Engineering. Part B, Reviews·Fiona E Freeman, Laoise M McNamara
Oct 28, 2017·Colloids and Surfaces. B, Biointerfaces·Yin YuanFosong Wang
Nov 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Boguslawa ŻywickaZbigniew Rybak
Jan 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei WuJianshu Li

❮ Previous
Next ❯

Citations

Sep 24, 2020·Journal of Biomaterials Science. Polymer Edition·Jianping MaoQing Cai
Sep 12, 2020·Journal of Tissue Engineering and Regenerative Medicine·Reza Eivazzadeh-KeihanMichael R Hamblin
Oct 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianyi ZhengXiaoping Yang
Dec 7, 2018·Developmental and Comparative Immunology·José A Fernández RobledoMichael J Metzger

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.