Bioresorbable scaffolds for percutaneous coronary interventions

Global Cardiology Science & Practice
Bill D Gogas

Abstract

Innovations in drug-eluting stents (DES) have substantially reduced rates of in-segment restenosis and early stent thrombosis, improving clinical outcomes following percutaneous coronary interventions (PCI). However a fixed metallic implant in a vessel wall with restored patency and residual disease remains a precipitating factor for sustained local inflammation, in-stent neo-atherosclerosis and impaired vasomotor function increasing the risk for late complications attributed to late or very late stent thrombosis and late target lesion revascularization (TLR) (late catch-up). The quest for optimal coronary stenting continues by further innovations in stent design and by using biocompatible materials other than cobalt chromium, platinum chromium or stainless steel for engineering coronary implants. Bioresorbable scaffolds made of biodegradable polymers or biocorrodible metals with properties of transient vessel scaffolding, local drug-elution and future restoration of vessel anatomy, physiology and local hemodynamics have been recently developed. These devices have been utilized in selected clinical applications so far providing preliminary evidence of safety showing comparable performance with current generation drug-eluting st...Continue Reading

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Citations

Apr 27, 2018·Journal of Cardiovascular Translational Research·Arturo GiordanoMaria Fiammetta Romano
Dec 5, 2018·ACS Applied Materials & Interfaces·Yongli QiJiandong Ding

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Methods Mentioned

BETA
dissections
scanning electron microscopy

Clinical Trials Mentioned

NCT01023789
NCT01425281
NCT01751906
NCT02173379
NCT01761578

Software Mentioned

DESolve
BIOSOLVE
PROGRESS

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