Bioresponsive and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules

Chemical Science
Jiating XuJun Lin

Abstract

Developing nanotheranostics responsive to tumor microenvironments has attracted tremendous attention for on-demand cancer diagnosis and treatment. Herein, a facile Mn-doping strategy was adopted to transform mesoporous silica coated upconversion nanoparticles (UCNPs) to yolk-like upconversion nanostructures which possess a tumor-responsive biodegradation nature. The huge internal space of the innovated nanocarriers is suitable for doxorubicin (DOX) storage, besides, the Mn-doped shell is sensitive to the intratumoral acidity and reducibility, which enables shell biodegradation and further accelerates the breakage of Si-O-Si bonds within the silica framework. This tumor-responsive shell degradation is beneficial for realizing tumor-specific DOX release. Subsequently, polyoxometalate (POM) nanoclusters that can enhance photothermal conversion in response to the tumor reducibility and acidity were modified on the surface of the silica shell, thereby achieving NIR-enhanced shell degradation and also preventing premature DOX leakage. The as-produced thermal effect of the POM couples with the chemotherapy effect of the released DOX to perform a synergetic chemo-photothermal therapy. Additionally, the shell degradation brings size shr...Continue Reading

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Citations

Aug 30, 2018·Advanced Materials·Jiani XieYuliang Zhao
Jan 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Danping LingLining Sun
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueping KongLixin Wu
Aug 28, 2020·Frontiers in Chemistry·Mengqian LiQi Shuai
Nov 2, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinhua WuYuhua Wang
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Nov 18, 2020·Current Pharmaceutical Design·Shivani Rai PaliwalRishi Paliwal
Sep 5, 2018·ACS Applied Materials & Interfaces·Shuangshuang RenLeiying Miao

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Methods Mentioned

BETA
fluorescence resonance
FRET
imaging technique
X-ray
xenograft

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