Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering

Current Pharmaceutical Design
Arti VashistMadhavan Nair

Abstract

The emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on-demand release carriers for the various bioactive agents, growth factors, live cells, various hydrophobic drugs and as extracellular matrices for tissue engineering. Present review is an attempt to highlight the recent systems explored for on-demand drug release and tissue engineering. It also gives an overview of the role of nanotechnology in the advancements of injectable hydrogels. The future prospects and challenges of these hydrogels have also been addressed.

Citations

Feb 28, 2018·Nanomedicine·Ajeet KaushikMadhavan Nair
Jul 19, 2018·Chemistry : a European Journal·Vânia M P VieiraDavid K Smith
Jun 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ting ZhangMiao Yu
Aug 19, 2020·Chemical Communications : Chem Comm·Anna K Patterson, David K Smith
Jan 1, 2020·Scientific Reports·Anshu KumariSharad Gupta
Jun 26, 2020·International Journal of Nanomedicine·Asail HendiHaider Butt
Feb 8, 2019·BioTechniques·Jane Ru ChoiAlistair C Cowie
Dec 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shijie ZhuoXiaowen Liu
May 19, 2018·Drug Discovery Today·Arti VashistMadhavan Nair
Aug 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabio ColellaLaura B Creemers
Jun 21, 2021·Signal Transduction and Targeted Therapy·Chenya ZhuoMingqiang Li
Aug 5, 2021·Chemistry : a European Journal·Carmen C PirasDavid K Smith
Oct 31, 2021·Nature Protocols·Soon Hee KimChan Hum Park

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