Biosensors for brain trauma and dual laser doppler flowmetry: enoxaparin simultaneously reduces stroke-induced dopamine and blood flow while enhancing serotonin and blood flow in motor neurons of brain, in vivo.

Sensors
Patricia A Broderick, Edwin H Kolodny

Abstract

Neuromolecular Imaging (NMI) based on adsorptive electrochemistry, combined with Dual Laser Doppler Flowmetry (LDF) is presented herein to investigate the brain neurochemistry affected by enoxaparin (Lovenox(®)), an antiplatelet/antithrombotic medication for stroke victims. NMI with miniature biosensors enables neurotransmitter and neuropeptide (NT) imaging; each NT is imaged with a response time in milliseconds. A semiderivative electronic reduction circuit images several NT's selectively and separately within a response time of minutes. Spatial resolution of NMI biosensors is in the range of nanomicrons and electrochemically-induced current ranges are in pico- and nano-amperes. Simultaneously with NMI, the LDF technology presented herein operates on line by illuminating the living brain, in this example, in dorso-striatal neuroanatomic substrates via a laser sensor with low power laser light containing optical fiber light guides. NMI biotechnology with BRODERICK PROBE(®) biosensors has a distinct advantage over conventional electrochemical methodologies both in novelty of biosensor formulations and on-line imaging capabilities in the biosensor field. NMI with unique biocompatible biosensors precisely images NT in the body, bl...Continue Reading

References

Jan 1, 1992·Experimental Brain Research·H MemezawaB K Siesjö
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Apr 1, 1970·Medical History·F Schiller
Jan 1, 1982·Journal of Neural Transmission·C MaterossiM Trabucchi
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·P Coyle
Nov 25, 1997·Annals of the New York Academy of Sciences·S JonasR Llinás
Jul 8, 2000·Neuropathology and Applied Neurobiology·B S AspeyM J Harrison
Jan 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MasadaR F Keep
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·V MaryJ M Stutzmann
Mar 29, 2002·Clinical and Experimental Pharmacology & Physiology·Thanh G PhanGeoffrey A Donnan
Jan 18, 2003·Lancet·P M RothwellUNKNOWN Carotid Endarterectomy Trialists' Collaboration
Mar 16, 2004·Stroke; a Journal of Cerebral Circulation·Kazuko SaitaDavid W Howells
Mar 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Atul AggarwalDavid J Schneider
Dec 25, 2004·Journal of Pineal Research·Malcolm R MacleodGeorey A Donnan
Oct 22, 2005·Annals of Neurology·Hakan AyWalter J Koroshetz
Aug 22, 2006·European Journal of Radiology·Jörg Ederle, Martin M Brown
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Aug 30, 2008·The New England Journal of Medicine·Bruce Furie, Barbara C Furie
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krzysztof PtakJeffrey C Smith
Apr 15, 2009·European Neurology·Maurizio PaciaroniGiancarlo Agnelli

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Citations

Sep 10, 2013·Biosensors & Bioelectronics·Muhammad Ali Syed
Jun 10, 2014·Physiological Measurement·John Allen, Kevin Howell
May 31, 2019·Lasers in Medical Science·M Z Ansari, A Mujeeb

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Methods Mentioned

BETA
biosensors
biosensor
dissection

Software Mentioned

Image J

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