Biosensors in chemical separations

Annual Review of Biophysics and Biomolecular Structure
H A FishmanR N Zare

Abstract

Identification of biomolecules in complex biological mixtures represents a major challenge in biomedical, environmental, and chemical research today. Chemical separations with traditional detection schemes such as absorption, fluorescence, refractive index, conductivity, and electrochemistry have been the standards for definitive identifications of many compounds. In many instances, however, the complexity of the biomixture exceeds the resolution capability of chemical separations. Biosensors based on molecular recognition can dramatically improve the selectivity of and provide biologically relevant information about the components. This review describes how coupling chemical separations with online biosensors solves challenging problems in sample analysis by identifying components that would not normally be detectable by either technique alone. This review also presents examples and principles of combining chemical separations with biosensor detection that uses living systems, whole cells, membrane receptors, enzymes, and immunosensors.

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Citations

Jul 29, 1999·Biophysical Journal·D V NicolauS Yoshikawa
Nov 18, 2005·Colloids and Surfaces. B, Biointerfaces·S A MitchellR H Bradley
Jun 30, 2006·Analytical and Bioanalytical Chemistry·Sara Rodriguez-MozazDamià Barceló
Sep 3, 2005·Annali Di Chimica·Marek Trojanowicz
Mar 18, 2011·Faraday Discussions·Seyed-Fakhreddin Torabi, Yi Lu
Dec 26, 2001·Chemical Reviews·Hagan Bayley, Charles R. Martin
Mar 23, 2007·Journal of the American Chemical Society·Xiao-feng KangHagan Bayley

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Methods Mentioned

BETA
NMR
biosensor
electrophoresis
surface plasmon resonance
biosensors
transfection
the
flow calorimetry
surface

Software Mentioned

CAS
SCISEARCH
BIAcore

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