Biosimilar drugs in oncology

Bulletin du cancer
Dominique Levêque

Abstract

Biosimilar drugs are biologic drugs clinically similar to the reference products. They correspond to a generic approach applied to biologic agents. Biosimilars are aimed to provide cheaper drugs by enhancing the concurrency. The approval of biosimilars is abbreviated when compared to that of the reference biologics but includes clinical trials (distinguishing them from the generics). Current available biosimilars in oncology are filgrastim and epoietin alpha. In the next future, will be launched rituximab and trastuzumab. In France, the development of biosimilars is faced with many hurdles that necessitates a better information of physicians and a greater price discount in the out-patient setting. More globally, harmonisation of recommendations particularly concerning extrapolation of indications and nomenclature are needed for a better acceptance.

References

Apr 12, 2011·Nature Biotechnology·Martin SchiestlRoger Grau
Sep 16, 2014·Drug Discovery Today·Michael S Kinch
Oct 10, 2014·Nature Biotechnology·Gary Walsh
Dec 3, 2014·Journal of Pharmaceutical Sciences·David B VolkinJohn F Carpenter

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Citations

Mar 28, 2016·Bulletin du cancer·Cécile WilkowskyStéphane Vignot
May 21, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Selma HadoussaMyriam R Khrouf
Sep 22, 2018·Clinical Journal of Oncology Nursing·Joseph D Tariman

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