Biosimilars for inflammatory bowel disease: how can healthcare professionals help address patients' concerns?

Expert Review of Gastroenterology & Hepatology
Krisztina B GecseGeert D'Haens

Abstract

The patent expiration of some biologics used in chronic conditions such as inflammatory bowel disease (IBD) has led to the development of biosimilar monoclonal antibodies. The tailored regulatory approval route for biosimilar development ensures that approved biosimilars show similarity to their originators in terms of efficacy and safety, and avoids unnecessary repetition of clinical trials carried out with the originator product. However, some patients may still have concerns about using biosimilars and it is the responsibility of healthcare professionals (HCPs) to alleviate these concerns. Areas covered: This review highlights clinical and real-world evidence supporting efficacy and safety of biosimilars in patients with IBD. Moreover, based on international surveys, potential patient concerns are highlighted, along with possible actions HCPs can take to address these concerns. Expert commentary: The rising use of biosimilars in IBD is expected to have a positive impact on the availability of biologics and healthcare costs. Several biosimilars have been approved for use and more are likely to come to the market in the future; however, transitioning patients to biosimilars could pose an unexpected challenge without the help a...Continue Reading

References

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Jul 2, 2017·Digestive Diseases and Sciences·Lisa J T SmitsFrank Hoentjen
Oct 17, 2017·Rheumatology and Therapy·Mourad F Rezk, Burkhard Pieper

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Citations

Jul 14, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Pavine L C LefevreNiels Vande Casteele
Feb 10, 2021·Pharmaceuticals·Yannick VandenplasIsabelle Huys

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