Biosynthesis and accumulation of sterols

Annual Review of Plant Biology
P Benveniste

Abstract

In recent years, the impressive development of molecular genetics tools, the sequencing of the Arabidopsis thaliana genome, the availability of DNA or transposon tagged mutants, and the multiple possibilities offered by stable transformation with DNA in sense and antisense orientation have enabled the application of a strategy of gain or loss of function to study the sterol biosynthesis pathway. Here we describe the results obtained with these techniques. The results essentially confirm data obtained previously with sterol biosynthesis inhibitors (SBIs) and enable the precise dissection of biosynthetic pathways. We discuss the advantages and disadvantages of molecular genetics techniques as applied to sterol metabolism. The greater selectivity of these techniques constitutes an invaluable advantage and has led to the discovery of a role for sterols in plant development.

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Citations

Mar 30, 2007·Lipids·Masashi Suzuki, Toshiya Muranaka
Apr 7, 2011·Applied Biochemistry and Biotechnology·Pankaj ChaturvediRakesh Tuli
May 11, 2011·The British Journal of Nutrition·Gérard Lizard
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Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kiyoshi OhyamaToshiya Muranaka
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Mar 9, 2011·Journal of Lipid Research·Vera WewerPeter Dörmann
May 6, 2014·Doklady. Biochemistry and Biophysics·A G SulkarnayevaF V Minibayeva
Feb 15, 2014·Molecular Phylogenetics and Evolution·Mariela L TomazicAlejandro D Nusblat
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Oct 16, 2014·Journal of Experimental Botany·Daniel F StuckyKathrin Schrick
Sep 12, 2015·Plant Signaling & Behavior·Syed SaemaPratibha Misra

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Methods Mentioned

BETA
transgenic
X-ray
glycosylation
dissection

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