Biosynthesis and characterization of copper oxide nanoparticles and its anticancer activity on human colon cancer cell lines (HCT-116)

Journal of Photochemistry and Photobiology. B, Biology
V GnanavelSelvaraj Mohana Roopan

Abstract

The eco-friendly synthesis of nanoparticles through green route from plant extracts have renowned a wide range of application in the field of modern science, due to increased drug efficacy and less toxicity in the nanosized mediated drug delivery model. In the present study, our research groups have biosynthesized the stable and cost effective copper oxide nanoparticles (CuO NPs) from the leaves of (Ormocarpum cochinchinense) O. cochinchinense. The synthesis of crystalline CuO NPs from the leaf extract of O. cochinchinense were confirmed by various analytical techniques like UV-Visible Spectroscopy (UV-Vis), Fourier-Transform Infrared Spectroscopy (FT-IR), X-Ray Diffractometer (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Selected Area Electron Diffraction (SAED) pattern. Further the synthesized CuO NPs were screened for anticancer activity on human colon cancer cell lines (HCT-116) by MTT (3-(4,5-dimethyl-2-tiazolyl)-2,5-diphenyl-2-tetrazolium bromide) assay. The obtained result inferred that the synthesized CuO NPs demonstrated high anticancer cytotoxicity on human colon cancer cell lines (HCT-116) with IC50 value of 40μgmL(-1) were discussed briefly in this manuscript.

Citations

Jul 7, 2019·Particle and Fibre Toxicology·Marit IlvesHarri Alenius
Mar 28, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Saad El-Din HassanMamdouh S El-Gamal
May 7, 2020·Advanced Pharmaceutical Bulletin·Mahmoud AbudayyakGül Özhan
Jun 6, 2018·Materials·Gregory MarslinGregory Franklin
Sep 2, 2019·International Journal of Biological Macromolecules·Devaraj BharathiV Bhuvaneshwari
Mar 7, 2021·Carbohydrate Polymers·Chandrasekaran KarthikeyanRotimi Sadiku
Jul 28, 2020·Heliyon·Sunday Adewale AkinteluAbel Kolawole Oyebamiji

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