PMID: 7336463Dec 1, 1981Paper

Biosynthesis and inactivation of ecdysone during the pupal-adult development of the cabbage butterfly, Pieris brassicae L

Steroids
P BeydonR Lafont

Abstract

Injection of labelled ecdysone and 2-hydroxyecdysone into Pieris pupae showed that their catabolism proceeds through 26-hydroxylation followed by conversion into acidic steroids assumed to be 26-oic compounds. This biological system is characterized by the lack of conjugation reactions and by rather long-lived hormones. In vivo biosynthesis of ecdysteroids was investigated by 24 hr [3H]cholesterol labelling, followed by HPLC analysis of the resulting [3H]ecdysone and 20-hydroxyecdysone. Active conversion (up to 0.07% in 24 hours) was observed between 48 hr and 120 hr following pupal ecdysis, a result in good agreement with the variations observed in hormone content. Long-term [3H]cholesterol incorporation experiments made it possible to monitor ecdysteroid dynamics during pupal development. Three periods were observed, corresponding to successive accumulation of ecdysone, 20-hydroxyecdysone and an acidic metabolite. Comparison of these results with those of the experiments involving labelled ecdysone injection shows that the catabolism of injected hormones is not the same as that of endogenous hormones.

References

Jan 1, 1977·Journal of Insect Physiology·R LafontJ L Pennetier
Dec 1, 1974·Journal of Insect Physiology·D H HornJ S Wilkie
Dec 1, 1974·Lipids·H N NiggS R Dutky
Sep 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·J KoolmanP Karlson
May 1, 1969·Steroids·R F Hutchins, J N Kaplanis
Aug 1, 1980·Japanese Journal of Medical Science & Biology·A Moribayashi, T Ohtaki

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Citations

Aug 5, 2000·Archives of Insect Biochemistry and Physiology·D B GelmanR A Bell
Mar 1, 1984·Steroids·F Lachaise, R Lafont
Jan 1, 1990·Archives of Insect Biochemistry and Physiology·G Sommé-MartinR Lafont

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