Biosynthesis and production of glycosylated flavonoids in Escherichia coli: current state and perspectives

Applied Microbiology and Biotechnology
Bong Gyu KimJoong-Hoon Ahn

Abstract

Flavonoids are plant secondary metabolites containing several hydroxyl groups that are targets for modification reactions such as methylation and glycosylation. In plants, flavonoids are present as glycones. Although glucose is the most common sugar attached to flavonoids, arabinose, galactose, glucuronic acid, rhamnose, and xylose are also linked to flavonoids. Depending on the kind and the position of the attached sugar, flavonoid glycones show different biological properties. Flavonoid-O-glycosides are synthesized by uridine diphosphate-dependent glycosyltransferases (UGTs), which use nucleotide sugar as a sugar donor and a diverse compound as a sugar acceptor. Recently, diverse flavonoid-O-glycosides have been synthesized in Escherichia coli by introducing UGTs from plants and bacteria and modifying endogenous pathways. The nucleotide sugar biosynthesis pathway in E. coli has been engineered to provide the proper nucleotide sugar for flavonoid-O-glycoside biosynthesis. In this review, we will discuss recent advances in flavonoid-O-glycoside biosynthesis using engineered E. coli.

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Citations

Mar 5, 2016·Journal of Industrial Microbiology & Biotechnology·Dae Gyun AnJoong-Hoon Ahn
Apr 1, 2016·Applied Microbiology and Biotechnology·Bernd Hofer
Jul 5, 2016·Journal of Biotechnology·Heike OverwinBernd Hofer
Mar 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fangmin DouBaoqing Dun
Dec 3, 2016·Frontiers in Microbiology·Ramesh P Pandey, Jae K Sohng
Apr 28, 2017·Journal of Experimental Botany·Tessa MosesAlain Goossens
Aug 14, 2019·Applied Microbiology and Biotechnology·Samir Bahadur ThapaJae Kyung Sohng
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanghang LouQihe Chen
Dec 16, 2021·Critical Reviews in Food Science and Nutrition·Xiaodan LiWeifeng Liu

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