Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola

Molecular Plant-microbe Interactions : MPMI
Wanessa D WightJonathan D Walton

Abstract

Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC). A chemically unrelated HDAC inhibitor, HC toxin, was earlier shown to be a major virulence factor in the interaction between Cochliobolus carbonum and its host, maize. In order to test whether depudecin is also a virulence factor for A. brassicicola, we identified the genes for depudecin biosynthesis and created depudecin-minus mutants. The depudecin gene cluster contains six genes (DEP1 to DEP6), which are predicted to encode a polyketide synthase (AbPKS9 or DEP5), a transcription factor (DEP6), two monooxygenases (DEP2 and DEP4), a transporter of the major facilitator superfamily (DEP3), and one protein of unknown function (DEP1). The involvement in depudecin production of DEP2, DEP4, DEP5, and DEP6 was demonstrated by targeted gene disruption. DEP6 is required for expression of DEP1 through DEP5 but not the immediate flanking genes, thus defining a coregulated depudecin biosynthetic cluster. The genes flanking the depudecin gene cluster but not the cluster itself are conserved in the same order in the related fungi Stagonospora nodorum and Pyrenophora tritici-repentis. Depudecin-...Continue Reading

References

Dec 1, 1974·Bulletin of Environmental Contamination and Toxicology·L G HammockJ E Casida
Feb 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·F HoshiS Kawamura
Oct 1, 1996·The Plant Cell·J D Walton
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·S J Darkin-RattrayD M Schmatz
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·D S MultaniG S Johal
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H J KwonS L Schreiber
Sep 4, 1999·The Plant Journal : for Cell and Molecular Biology·B P ThommaW F Broekaert
Mar 29, 2000·Bioscience, Biotechnology, and Biochemistry·M TanakaK Nabeta
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·L Tian, Z J Chen
Aug 11, 2001·Science·T Jenuwein, C D Allis
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·K F Pedley, J D Walton
Jan 1, 1992·The Plant Cell·R. B. MeeleyJ. D. Walton
Nov 26, 2002·The Plant Journal : for Cell and Molecular Biology·Alessandra DevotoJohn G Turner
Apr 16, 2003·The Plant Journal : for Cell and Molecular Biology·Keqiang WuBrian Miki
Jan 21, 2004·Fungal Genetics and Biology : FG & B·Robert A Cramer, Christopher B Lawrence
Mar 24, 2004·The Journal of Biological Chemistry·Stefan MalonekBettina Tudzynski
Jul 31, 2004·Archives of Pharmacal Research·Ki Eun JoungYhun Yhong Sheen
Oct 27, 2004·The Plant Journal : for Cell and Molecular Biology·Paola VeroneseTesfaye Mengiste
Nov 6, 2004·Applied and Environmental Microbiology·Shuguang ZhangBarry Scott
Jan 12, 2005·European Journal of Medicinal Chemistry·Claude Monneret
Aug 23, 2005·FEMS Microbiology Letters·Alongkorn AmnuaykanjanasinMorakot Tanticharoen
May 23, 2006·Journal of Biotechnology·W J H van BerkelM W Fraaije
Jul 15, 2006·Phytochemistry·Jonathan D Walton
Oct 19, 2007·Nucleic Acids Research·Karla GendlerCarolyn Napoli
Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anoop SindhuGurmukh S Johal
Apr 4, 2008·Cellular Microbiology·Timothy L FriesenRichard P Oliver
Apr 10, 2008·The Plant Journal : for Cell and Molecular Biology·Jens StaalChristina Dixelius

❮ Previous
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Citations

Apr 9, 2013·Applied Microbiology and Biotechnology·Perng-Kuang Chang, Kenneth C Ehrlich
Jul 1, 2011·The Journal of Microbiology·Wenbing Yin, Nancy P Keller
Sep 4, 2012·The Journal of Organic Chemistry·Yit-Heng Chooi, Yi Tang
Jul 20, 2013·BMC Microbiology·Wanessa D WightJonathan D Walton
Jan 28, 2014·PloS One·Jérôme CollemarePierre J G M de Wit
Jan 1, 2010·The Arabidopsis Book·Kristin Laluk, Tesfaye Mengiste
Jun 26, 2014·Cancer Letters·Michael SchnekenburgerMarc Diederich
Jan 25, 2016·International Journal of Food Microbiology·Erik LysøeUlf Thrane
Nov 3, 2015·Molecular Plant-microbe Interactions : MPMI·Qian-Hao ZhuMing-Bo Wang
Jan 31, 2016·Fungal Genetics and Biology : FG & B·Daren W Brown, Robert H Proctor
Jun 10, 2011·The New Phytologist·Stéphane BourqueDavid Wendehenne
Nov 25, 2011·Molecular Plant Pathology·Javier A DelgadoRubella S Goswami
Jul 14, 2010·Molecular Plant Pathology·María E AlvarezDamián A Cambiagno
Jun 22, 2010·Biopolymers·Jonathan D WaltonHong Luo
Oct 8, 2014·The Plant Pathology Journal·Junhyun JeonYong-Hwan Lee
Apr 12, 2017·The Journal of Organic Chemistry·Iván Cheng-SánchezFrancisco Sarabia
May 2, 2017·Molecular Biology and Evolution·Hannah T ReynoldsDaren W Brown
Mar 10, 2019·The New Phytologist·Jérôme CollemareMarc-Henri Lebrun
Jun 25, 2017·Annual Review of Phytopathology·H Charlotte van der Does, Martijn Rep
May 19, 2020·Molecular Biology and Evolution·Emile Gluck-ThalerJason C Slot
Jun 21, 2018·Frontiers in Microbiology·Koen HoogendoornMarnix H Medema
Jun 12, 2019·International Journal of Molecular Sciences·Junjie YinJing Wang
Apr 5, 2018·Frontiers in Plant Science·Juan S Ramirez-PradoMoussa Benhamed
Dec 17, 2020·International Journal of Molecular Sciences·Christelle El Hajj AssafSophie Lorber
Mar 23, 2021·Frontiers in Plant Science·Kaushal Pratap SinghPramod Kumar Rai
Apr 17, 2021·Microbiology Resource Announcements·Anastasia Landeis, Markus Schmidt-Heydt

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