Biosynthesis, characterization and cytotoxicity of gold nanoparticles and their loading with N-acetylcarnosine for cataract treatment

Journal of Photochemistry and Photobiology. B, Biology
Yan WangTao Peng

Abstract

The present work showed the biofabrication and characterization of gold nanoparticles (Au NPs) using Coccinia grandis bark extract. The fabricated NPs were well characterized by using different microscopic an spectroscopic techniques such as transmission electron microscopy (TEM), Ultra violet - visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Energy dispersive spectroscopy (EDS) and Fourier transform spectroscopy (FTIR). TEM results showed that the prepared AuNPs are spherical in shape with uniformity in size. The calculated average size of the AuNPs is 20 nm. The NAC drug molecule that is used for cataract treatment was successfully encapsulated into Au NPs to increase its bioavailability. Also, the in-vitro cytotoxicity of NAC and NAC - Au NPs were studied against fibroblast cells, and the results showed that encapsulation of NAC into Au NPs did not showed cytotoxicity after encapsulation. NAC molecules do not exhibit toxicity at lower concentrations, While, there is a reduction in the number of viable cells at higher concentration of NAC. Also, the encapsulation of the drug onto Au NPs is considerably increased biocompatibility and bioavailability. In future, this research results may be helpful for the development o...Continue Reading

Citations

Dec 31, 2019·Recent Patents on Drug Delivery & Formulation·Zufika QamarSanjula Baboota
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ema BurlacuLavinia Berta
Oct 16, 2020·Biomaterials Science·Fang ChenDavid Myung
Apr 20, 2021·Heliyon·Sunday Adewale AkinteluAderonke Similoluwa Folorunso
Aug 24, 2021·Journal of Toxicology·Chukwuebuka EgbunaChinwe Gloria Ibeabuchi

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