PMID: 6989408Apr 17, 1980Paper

Biosynthesis of biopterin in Ascaris lumbricoides suum

Biochimica Et Biophysica Acta
H OtsukaM Goto

Abstract

In in vivo experiments, radioactivity from [U-14C]GTP was incorporated into biopterin, and, in fact, all carbon atoms of biopterin synthesized in Ascaris lumbricoides suum originated from GTP. Biopterin was also biosynthesized in homogenates of tissue fluid and muscles of Ascaris lumbricoides suum. The enzyme which catalyzes sepiapterin synthesis from D-erythro-7,8-dihydroneopterin-3'-phosphate was found in A. lumbricoides suum extracts and extracted in the 0--30% (NH4)2SO4 fraction from a 40 000 x g supernatant. The enzyme was purified by Sephadex G-200 column and DEAE-cellulose column chromatography. It is suggested that sepiapterin could be an intermediate compound in biopterin biosynthesis.

References

Aug 1, 1970·Archives of Biochemistry and Biophysics·T Fukushima
Dec 1, 1970·Experimental Parasitology·T Fukushima
Dec 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·S Kaufman
May 1, 1964·Endocrinology·K TORIZUKAJ B STANBURY
Apr 19, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Gregory T Roman, Christopher T Culbertson

Citations

Jan 1, 1984·Neurochemistry International·D HeintelR A Levine
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A NicholD S Duch
Jun 1, 1987·Archives of Biochemistry and Biophysics·G K Smith
Jan 1, 1981·Medicinal Research Reviews·J J McCormack

Related Concepts

Sepiapterin
Sepiapterin synthase
Alcohol Oxidoreductases
Ascaris
Orinapterin
Body Fluids
Chromatography, DEAE-Cellulose
Molecular Sieve Chromatography
Guanosine Triphosphate
Multienzyme Complexes

Related Feeds

Ascariasis (ASM)

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.

Ascariasis

Ascariasis is a helminthic infection of global distribution with more than 1.4 billion persons infected throughout the world. Here is the latest research.