Biosynthesis of cytidine nucleotides in rat liver after administration of D-galactosamine

Chemico-biological Interactions
J Seifert, E Buchar

Abstract

Following the administration of D-galactosamine the utilization of [2-14C] orotic acid for the synthesis of the cytidine components of the acid-soluble extract and liver RNA cytosine is markedly decreased. The depression of the specific activity of the cytidine components takes place after application of low doses of the drug which do not interfere with the specific activity of the uridine components of the acid-soluble extract or of liver RNA uracil. Simultaneously the administration of [U-14C]cytidine paralleled by its enhanced liver uptake. The total amount of uridine as well as cytidine components of the acid-soluble extract following the administration of D-galactosamine increases; however, the molar ratio of both pyrimidines does not change. The alterations of the cytidine metabolism after the administration of the drug are accompanied by the increased level of microsomal cytochrome P-450.

References

May 31, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Seifert, E Buchar
Jan 5, 1978·Nature·J C WilliamsH P Morris
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D M HelfmanJ F Kuo
Mar 1, 1975·Archives of Biochemistry and Biophysics·J Seifert, J Vácha
Dec 23, 1974·Biochemical and Biophysical Research Communications·F Possmayer
Jun 4, 1974·Biochemical and Biophysical Research Communications·A Bloch
Apr 1, 1970·Experimental and Molecular Pathology·A MedlineH Popper
Oct 1, 1968·Experimental and Molecular Pathology·D KepplerK Decker

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Citations

Jan 1, 1985·Advances in Enzyme Regulation·D KepplerT Gasser
Jul 13, 2001·Plant Science : an International Journal of Experimental Plant Biology·H AshiharaT A. Thorpe
Mar 1, 1987·Archives internationales de physiologie et de biochimie·J Olivares, A Rossi

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