PMID: 60236Jul 15, 1976Paper

Biosynthesis of gramicidin S with the aid of dipeptides by gramicidin S synthetase

European Journal of Biochemistry
A von DungenH Kleinkauf

Abstract

Dipeptides L-phenylalanyl-proline, D-phenylalanyl-proline, prolyl-valine, valyl-lysine, lysyl-leucine and leucyl-phenylalanine, derived from the sequence of gramicidin S, are substrates of the gramicidin S synthetase. When any of these dipeptides are used to replace the two corresponding amino acids in the reaction assay, cyclodecapeptide antibiotic synthesis occurs, and requires the whole multienzyme system. Active esters, like the thiophenyl and p-nitrophenyl esters of D-phenylalanyl-proline are unable to promote gramicidin S biosynthesis with the gramicidin S synthetase system or with the heavy enzyme alone.

References

May 13, 1976·Biochimica Et Biophysica Acta·H Koischwitz, H Kleinkauf
Jan 1, 1974·Annual Review of Biochemistry·K Kurahashi
May 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·W GeversF Lipmann
Apr 1, 1971·Archives of Biochemistry and Biophysics·R RoskoskiF Lipmann
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·W GeversF Lipmann

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