PMID: 11918068Mar 29, 2002Paper

Biosynthesis of hibarimicins. III. Structures of new hibarimicin-related metabolites produced by blocked mutants

The Journal of Antibiotics
Yasuhiro IgarashiT Oki

Abstract

Structures of metabolites produced by blocked mutants of Microbispora rosea subsp. hibaria TP-A0121, hibarimicin-producer, were determined by spectroscopic analysis. HMP-Y6 is the dimer of the west half of hibarimicin B, the aglycon of which is the genuine biosynthetic intermediate. HMP-P1 is the shunt product arising from the release of a methanol molecule from hibarimicinone. HMP-P4, the glycoside of HMP-P1, is glycosylated with two amicetoses and two digitoxoses same as hibarimicin B. HMP-M1, M2, M3 and M4 are shunt products derived from the monomeric undecaketide intermediates.

Citations

Jun 30, 2012·European Journal of Organic Chemistry·Jialiang LiDavid R Mootoo
Apr 16, 2014·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kuniaki Tatsuta, Seijiro Hosokawa
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson
Mar 28, 2013·The Journal of Antibiotics·Kuniaki Tatsuta
Aug 5, 2011·Organic Letters·Ian M RomaineGary A Sulikowski
Nov 17, 2011·Organic Letters·Benjamin C MilgramMatthew D Shair
Sep 14, 2012·Journal of the American Chemical Society·Brian B LiauMatthew D Shair

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