PMID: 6403365Mar 1, 1983Paper

Biosynthesis of lipoxygenase products by ocular tissues

Experimental Eye Research
R N WilliamsK E Eakins

Abstract

The metabolism of arachidonic acid via the lipoxygenase pathway has been investigated in conjunctival and iris tissue taken from eyes of various species. In addition we have also studied two inhibitors of arachidonate metabolism, BW 755 and indomethacin, on albino rabbit ocular tissues. The ocular tissues of most species (monkey, dog, cat, rabbit, guinea-pig and rat) formed lipoxygenase products from exogenous arachidonic acid. The exception was the albino rabbit iris, where no lipoxygenase product was detected. The major lipoxygenase product found was 12-HETE, although 5-HETE and 5,12-diHETE were formed to a lesser extent by the conjunctiva and iris of the Dutch rabbit. The rat ocular tissues and guinea pig conjunctiva also formed 5-HETE. In the conjunctiva of the albino rabbit, indomethacin was a relatively specific inhibitor of the cyclo-oxygenase pathway whereas BW 755 inhibited both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism. In view of the possible roles of lipoxygenase products in inflammatory reactions and the ability of ocular tissues to synthesize these products, dual inhibitors of cyclo-oxygenase and lipoxygenase pathways may be useful agents to control ocular inflammatory responses.

References

Feb 1, 1974·British Journal of Pharmacology·P Bhattacherjee, K E Eakins
Nov 25, 1973·Experimental Eye Research·D F Cole, W G Unger
Jul 17, 1981·European Journal of Pharmacology·P BhattacherjeeK E Eakins

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Citations

Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T Pahlitzsch, P Sinha
Feb 24, 1987·European Journal of Pharmacology·D Garceau, A W Ford-Hutchinson
Nov 3, 1987·European Journal of Pharmacology·D GarceauS Charleson
Apr 1, 1986·Prostaglandins·C S SpadaA L Nieves
Jun 1, 1986·Prostaglandins·P S Kulkarni, B D Srinivasan
Jun 1, 1991·Prostaglandins·A H Krauss, D F Woodward
Jan 1, 1989·Pharmacology & Therapeutics·M F Sugrue
Mar 22, 2002·Acta Ophthalmologica Scandinavica·Ralf KuckelkornClaudia Redbrake
Jan 1, 1991·Journal of Ocular Pharmacology·S Sakamoto, H Shichi
Apr 1, 1989·Acta Physiologica Scandinavica·K Andersson
Nov 15, 1994·Annals of the New York Academy of Sciences·A R BrashW Song
Apr 1, 1987·Journal of Aging Studies·S Reinharz
Dec 1, 1985·Experimental Eye Research·R N WilliamsC A Paterson
May 1, 1985·Australian and New Zealand Journal of Ophthalmology·S MishimaK Masuda
Apr 28, 2004·The Veterinary Clinics of North America. Small Animal Practice·Bradford J Holmberg, David J Maggs
Oct 15, 1985·Biochemical and Biophysical Research Communications·M L SchwartzmanJ C McGiff
May 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·D A Wilkie
Mar 1, 1984·Current Eye Research·P S KulkarniB D Srinivasan
Jan 1, 1994·Journal of Ocular Pharmacology·T AsakuraH Shichi
Jan 1, 1988·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C P HerbortM Mochizuki
Jan 1, 1986·Progress in Lipid Research·G A Higgs
Mar 1, 1986·Infection and Immunity·R V WatersG H Jones
Jul 1, 1993·Survey of Ophthalmology·M B Abelson, K Schaefer
Jul 1, 1986·Experimental Eye Research·R N Williams, C A Paterson

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