PMID: 168873Feb 1, 1975Paper

Biosynthesis of phosphatidylethanolamines and phosphatidylcholines from ethanolamine and choline in rat liver

The Biochemical Journal
R Sundler, B Akesson

Abstract

1. The kinetics of phosphatidylcholine and phosphatidylethanolamine synthesis in rat liver were followed 5-60 min after the intraportal injection of [14-C]choline and [3-H]-ethanolamine. 2. At all time-intervals the specific radioactivity of CDP-choline was only about half that of phosphorylcholine. This indicated that CDP-choline was formed at a similar rate from phosphorylcholine and phosphatidylcholines, the latter probably through the reverse reaction of cholinephosphotransferase (EC 2.7.8.2.). In view of recent data obtained from experiments in vitro this implies a significant role for the cholinephosphotransferase reaction in the turnover of molecular species of phosphatidylcholine. 3. The specific radioactivity of CDP-ethanolamine was about twice that of phosphorylethanolamine at all time-intervals studied. This supports a previous suggestion that the liver phosphorylethanolamine pool is subject to compartmentation and shows that there is no rapid equilibration between different pools. In contrast with a recent study, no evidence was found for any significant methylation of phosphoryl-or CDP-ethanolamine to the corresponding choline derivative. 4. Quantitative data on the biosynthesis of molecular species of phosphoLIPID...Continue Reading

Citations

Apr 1, 1978·European Journal of Biochemistry·H Kanoh, B Akesson
Mar 9, 2011·Progress in Lipid Research·Martin HermanssonPentti Somerharju
Dec 28, 1979·Brain Research·J K BlusztajnRichard J Wurtman
Aug 11, 2012·Biochimica Et Biophysica Acta·D E Vance
Sep 11, 2012·Biochimica Et Biophysica Acta·J E Vance, Guergana Tasseva
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J E Vance, D E Vance
Dec 1, 1988·Journal of Cellular Physiology·B A LiptonB H Ginsberg
May 23, 1976·Biochemical and Biophysical Research Communications·F A Shamgar, F D Collins
May 15, 1989·Biochemical and Biophysical Research Communications·L B TijburgL M Van Golde
Jun 15, 1990·Experientia·J E Vance, D E Vance
Mar 1, 1979·The British Journal of Nutrition·B AkessonM Jägerstad
Nov 2, 2013·World Journal of Hepatology·Stephan LaggaiSonja M Kessler
Jul 3, 2020·The Journal of Cell Biology·Michelle Grace AcobaSteven M Claypool
Sep 30, 2005·The Journal of Biological Chemistry·Rineke SteenbergenJ E Vance
Oct 19, 2018·Nutrients·Alejandra M WiedemanDavid D Kitts
Oct 24, 2020·The Journal of Biological Chemistry·Mahtab TavasoliChristopher R McMaster
Jan 20, 2021·Metabolomics : Official Journal of the Metabolomic Society·Emily G ArmitageAmy J Naylor
Jan 18, 2021·The Journal of Biological Chemistry·Mahtab TavasoliChristopher R McMaster

Related Concepts

Anthropoidea
Choline Hydroxide
Diacylglycerol Cholinephosphotransferase
Citicoline
Ethanolamines
Liver
Phosphatidylcholines
Phosphatidylethanolamines
Phospholipids

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.