PMID: 7899493Jan 1, 1995Paper

Biosynthesis of pteridines in Neurospora crassa, Phycomyces blakesleeanus and Euglena gracilis: detection and characterization of biosynthetic enzymes

Photochemistry and Photobiology
J Maier, H Ninnemann

Abstract

Occurrence, biosynthesis and some functions of tetrahydrobiopterin (H4biopterin) in animals are well known. The biochemistry of H4biopterin in other organisms than animals was hitherto not widely investigated. Recently H4biopterin was found in the phytoflagellate Euglena gracilis, in the zygomycete Phycomyces blakesleeanus and in the ascomycete Neurospora crassa. In Euglena, Neurospora and Phycomyces the enzymatic activities of GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are detectable and the biosynthesis follows the same steps as were shown for animals. The biosynthetic enzymes, however, show a much lower sensitivity to those inhibitors that act on vertebrate enzymes. 2,4-Diamino-6-hydroxypyrimidine as inhibitor of GTP cyclohydrolase I and N-acetylserotonin or N-methoxyacetylserotonin as inhibitors of sepiapterin reductase can decrease pteridine biosynthesis significantly, in vitro and in vivo. The apparent Km values are in general higher when compared with the respective animal enzymes. In Neurospora, the conversion of GTP to dihydroneopterin triphosphate was closely associated with subsequent production of 6-hydroxymethyl-7,8-dihydropterin due to the high activity of dihydroneopterin...Continue Reading

References

Aug 1, 1992·Trends in Genetics : TIG·L M Corrochano, E Cerdá-Olmedo
Feb 1, 1992·Photochemistry and Photobiology·N HohlH Senger
Nov 1, 1991·Biological Chemistry Hoppe-Seyler·G KatzenmeierA Bacher
Mar 29, 1991·Biochemical and Biophysical Research Communications·Y S ParkN Blau
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M D DavisS Milstien
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K TanakaS Milstien
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L JohnsonA Sancar
Dec 1, 1985·Photochemistry and Photobiology·D Siefermann-HarmsH Ninnemann
Apr 14, 1988·Biochimica Et Biophysica Acta·R S ShenY X Zhang
Jan 1, 1985·Journal of Cellular Biochemistry·I Ziegler
Jan 1, 1970·Biochemical and Biophysical Research Communications·D S Berns, J R Vaughn
Jul 1, 1984·Zeitschrift Für Naturforschung. Section C: Biosciences·R M Fink, E F Elstner
Aug 5, 1984·Nature·G R Fink, T D Petes
Apr 20, 1983·Biochimica Et Biophysica Acta·S I YoshiokaM Akino
Feb 1, 1980·Analytical Biochemistry·T Fukushima, J C Nixon
Jan 1, 1993·Advances in Experimental Medicine and Biology·J Maier, I Ziegler
Jan 1, 1993·Advances in Experimental Medicine and Biology·G Cremer-BartelsK Krause
Feb 1, 1975·Plant Physiology·V Muñoz, W L Butler
Jun 1, 1990·Photochemistry and Photobiology·Paul GallandDonat-P Häder

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Citations

Nov 4, 2005·Analytical Biochemistry·Eoin P QuinlivanJesse F Gregory
May 20, 1999·The Biochemical Journal·S H ChoS O Kang
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Supangat SupangatKon Ho Lee
Dec 5, 2012·International Journal of Molecular Sciences·Yoon-Jung MoonYoung-Ho Chung
Mar 15, 2016·Frontiers in Plant Science·Magdalena Arasimowicz-Jelonek, Jolanta Floryszak-Wieczorek
May 14, 2014·Molecular Plant Pathology·Magdalena Arasimowicz-Jelonek, Jolanta Floryszak-Wieczorek
Jun 20, 2014·Photochemistry and Photobiology·Junko TakedaMasakatsu Watanabe
Dec 25, 2004·Developmental Biology·Sylvie Le GuyaderSuresh Jesuthasan
May 29, 2000·Photochemistry and Photobiology·A Portwich, F Garcia-Pichel
Jan 1, 1995·Photochemistry and Photobiology·H Ninnemann

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