PMID: 6413248Mar 21, 1983Paper

Biosynthesis of rabbit haptoglobin: chemical evidence for a single chain precursor

FEBS Letters
V ChowA Kurosky

Abstract

The primary translation product of the mRNA for rabbit haptoglobin was obtained from a rabbit reticulocyte lysate cell-free system by immunoprecipitation with an antiserum that was directed to the beta chain of haptoglobin. Analysis of the translation product by gel electrophoresis and by protein sequencing analysis identified a single polypeptide of Mr 41 000. Sequence analysis established a signal region of 18 residues that was immediately followed by the alpha chain sequence. These results give strong evidence that haptoglobin is initially synthesized as a single chain composed of a signal peptide followed by alpha and beta chain regions, respectively.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D Shields, G Blobel
Nov 28, 1978·Biochemistry·D J McKean, R A Maurer
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A KuroskyB Touchstone
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Apr 1, 1972·The Journal of Experimental Zoology·J C Travis, B G Sanders
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A KuroskyW M Fitch

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Citations

Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F YangB H Bowman
Jul 11, 1984·Nucleic Acids Research·M E Watson

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