Biosynthesis of sphinganine-analog mycotoxins.

Journal of Industrial Microbiology & Biotechnology
L DuQ Wang

Abstract

Sphinganine-analog mycotoxins (SAMT) are polyketide-derived natural products produced by a number of plant pathogenic fungi and are among the most economically important mycotoxins. The toxins are structurally similar to sphinganine, a key intermediate in the biosynthesis of ceramides and sphingolipids, and competitive inhibitors for ceramide synthase. The inhibition of ceramide and sphingolipid biosynthesis is associated with several fatal diseases in domestic animals and esophageal cancer and neural tube defects in humans. SAMT contains a highly reduced, acyclic polyketide carbon backbone, which is assembled by a single module polyketide synthase. The biosynthesis of SAMT involves a unique polyketide chain-releasing mechanism, in which a pyridoxal 5'-phosphate-dependent enzyme catalyzes the termination, offloading and elongation of the polyketide chain. This leads to the introduction of a new carbon-carbon bond and an amino group to the polyketide chain. The mechanism is fundamentally different from the thioesterase/cyclase-catalyzed polyketide chain releasing found in bacterial and other fungal polyketide biosynthesis. Genetic data suggest that the ketosynthase domain of the polyketide synthase and the chain-releasing enzyme...Continue Reading

References

Feb 1, 1992·Mycopathologia·R D Plattner, D D Shackelford
Sep 1, 1993·Journal of Animal Science·W D PriceD G McChesney
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·W WangM B Dickman
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BrownT J Leonard
Jan 1, 1996·Advances in Experimental Medicine and Biology·H K AbbasG A Kraus
Jan 1, 1996·Advances in Experimental Medicine and Biology·B A BlackwellJ D Miller
Jan 1, 1996·Advances in Experimental Medicine and Biology·C K WinterC Jones
Nov 1, 1996·Chemistry & Biology·R H LambalotC T Walsh
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·J T KealeyP J Barr
Jul 17, 1998·Current Opinion in Chemical Biology·C T WalshR S Flugel
Jun 11, 1999·Fungal Genetics and Biology : FG & B·L E BingleC M Lazarus
Jul 1, 1999·FEMS Microbiology Letters·M J Sweeney, A D Dobson
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·B F BrandwagtH J Nijkamp
Jun 29, 2000·Annual Review of Biochemistry·C KhoslaD E Cane
Aug 10, 2000·Metabolic Engineering·M T RichardsonC Khosla
Mar 17, 2001·Chemistry & Biology·T P NicholsonR J Cox
Sep 8, 2001·Natural Product Reports·J Staunton, K J Weissman
Feb 20, 2002·Chemical Reviews·David A. Hopwood
Feb 20, 2002·Chemical Reviews·Robert E. Minto, Craig A. Townsend
Mar 21, 2002·Natural Product Reports·Bradley S Moore, Christian Hertweck
Mar 7, 2003·Fungal Genetics and Biology : FG & B·Robert H ProctorAnne E Desjardins
May 24, 2003·Journal of Natural Products·Palangpon KongsaereeSuthep Wiyakrutta
Jun 5, 2003·Biochimica Et Biophysica Acta·Kentaro Hanada

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Citations

Jan 26, 2010·The Journal of Biological Chemistry·Anke PennoThorsten Hornemann
Jul 11, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·T BartókÁ Mesterházy
May 24, 2008·Journal of Lipid Research·Sarah T PruettAlfred H Merrill
Nov 28, 2013·The Journal of Antibiotics·Jacob R WinnikoffWilliam H Gerwick
Oct 5, 2014·Fungal Genetics and Biology : FG & B·Antonia SuscaAntonio Moretti
Aug 24, 2017·Proteomics·Taotao LiYueming Jiang
Sep 3, 2008·Medical Mycology·Jens C FrisvadThomas O Larsen
Jan 30, 2010·Natural Product Reports·Liangcheng Du, Lili Lou
Sep 8, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas Chaillou, Johanna T Lanner
Sep 21, 2012·Journal of Agricultural and Food Chemistry·Silvio UhligRobert Proctor

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