PMID: 6406412Apr 1, 1983Paper

Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis

The Journal of Antibiotics
L H Hurley, J S Rokem

Abstract

The biosynthesis of the antitumor antibiotic, CC-1065, has been investigated by radioactive isotope techniques, in combination with chemical degradation of CC-1065. Tyrosine, dopa, serine and methionine (S-CH3 group) have been shown to be precursors of CC-1065. Tyrosine is proposed to be a precursor of all three benzodipyrrole subunits, while dopa is only apparently incorporated into subunits B and C. Serine is postulated to contribute three 2C units, with loss of C-1, to all three subunits of CC-1065. The S-CH3 group of methionine probably contributes four C-1 units to CC-1065 of which one is incorporated with considerable loss of tritium, most probably into the cyclopropane ring of subunit A.

Citations

Dec 6, 2014·The Journal of Biological Chemistry·Matthew R BauerleSquire J Booker
Jul 11, 2019·Natural Product Reports·Wen-Bing JinGong-Li Tang
Apr 10, 2003·Chemical Reviews·Ludger A WessjohannThies Thiemann
Jan 1, 1985·Biotechnology Advances·L C Vining
Apr 21, 2017·ACS Chemical Biology·Sheng WuGong-Li Tang
Oct 28, 2019·Biochemistry·Liju G MathewWilliam N Lanzilotta

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