Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae)

Phytochemistry
Dirk UmlaufKlaus Peter Adam

Abstract

The incorporation of [1-13C]-labeled glucose into the irregular monoterpene artemisia ketone, the regular monoterpenes camphor and beta-thujone, the sesquiterpene germacrene D, the diterpene trans-phytol and beta-sitosterol and isofucosterol has been studied in axenic cultures of Tanacetum vulgare L. (Asteraceae). Quantitative 13C NMR spectroscopic analysis of the resulting labeling patterns showed that the isoprene units of the monoterpenes and the diterpene are formed via the methylerythritol phosphate (MEP) pathway, whereas the isoprene building blocks of the sesquiterpene and the sterols originate from the mevalonic acid (MVA) pathway.

References

Apr 1, 1968·Experimental Cell Research·O L GamborgK Ojima
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·D ArigoniM H Zenk
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·B M LangeR Croteau
Aug 27, 1999·Archives of Biochemistry and Biophysics·K P AdamJ Zapp
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·F RohdichM H Zenk
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·H LüttgenW Eisenreich
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S HerzF Rohdich
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·S HechtF Rohdich
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Felix RohdichWolfgang Eisenreich
May 9, 2003·Natural Product Reports·Tomohisa Kuzuyama, Haruo Seto

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Citations

Oct 15, 2010·Archives of Pharmacal Research·Ming Shan ZhengJong-Keun Son
Jun 4, 2008·Chemical & Pharmaceutical Bulletin·Guang-Hua XuSeung-Ho Lee
Jan 29, 2005·Organic & Biomolecular Chemistry·John W van KlinkNigel B Perry
Jul 28, 2005·Natural Product Reports·Braulio M Fraga
Dec 27, 2011·Progress in Lipid Research·Andréa HemmerlinThomas J Bach
Jun 19, 2010·Phytochemistry·Nishi Srivastava, Anand Akhila
Jul 14, 2010·Phytochemistry·Devin R PolichukPatrick S Covello
Nov 26, 2009·Phytochemistry·Nicholas SchramekWolfgang Eisenreich
Nov 23, 2006·Journal of Ethnopharmacology·Sanaa LahlouBadiaâ Lyoussi
Sep 12, 2006·Journal of Ethnopharmacology·Michele Luciane DickelMara Rejane Ritter
May 29, 2015·PloS One·Mark D HuynhJoshua A Udall
Sep 14, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christos LioliosIoanna Chinou
Oct 4, 2016·Veterinary Parasitology·Surapan JitviriyanonNuanchan Paraksa
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangyao DongMaitinuer Maiwulanjiang
Jul 27, 2020·Phytochemical Analysis : PCA·Randolph R J ArrooMeng F Wang

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