Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Organic & Biomolecular Chemistry
Takayoshi Awakawa, Ikuro Abe

Abstract

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. Its unique structure and bioactivity have drawn vast interest from chemists and biologists, and numerous isolation and bioactivity studies on this molecule have been performed. Recently, its biosynthetic enzymes were identified, and some of their crystal structures were reported. In this review, we describe the isolation of teleocidin derivatives, biosynthetic studies, and detailed analyses of biosynthetic enzymes, to clarify their biosynthetic reactions toward the enzymatic synthesis of bioactive teleocidin compounds.

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Citations

Dec 5, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hiromichi Egami, Yoshitaka Hamashima
Oct 28, 2019·Natural Product Reports·Jeffrey D Rudolf, Chin-Yuan Chang
Dec 24, 2018·Organic & Biomolecular Chemistry·Manojkumar G Kalshetti, Narshinha P Argade
Mar 18, 2020·Journal of Natural Medicines·Takahiro Mori
Nov 11, 2020·Natural Product Reports·Jeffrey D RudolfZining Li
Jan 22, 2021·Accounts of Chemical Research·David S PetersPhil S Baran
Mar 7, 2021·Journal of Natural Medicines·Takayoshi Awakawa
Jan 15, 2019·Journal of the American Chemical Society·Hugh NakamuraPhil S Baran
Sep 29, 2021·Natural Product Reports·Jonathan A SwainMargaret A Brimble

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Methods Mentioned

BETA
X-ray
geranylation

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