PMID: 8962048Dec 10, 1996Paper

Biosynthesis of vitamin B12: concerning the identity of the two-carbon fragment eliminated during anaerobic formation of cobyrinic acid

Proceedings of the National Academy of Sciences of the United States of America
J WangA I Scott

Abstract

It has been proved that, during anaerobic biosynthesis of the corrin macrocycle, the two-carbon fragment excised from the precursor, precorrin-3, is acetaldehyde, which originates from C-20 and its attached methyl group. This apparently contradictory finding is rationalized in terms of the subsequent enzymatic oxidation of acetaldehyde to acetic acid, which was previously regarded as the volatile fragment released by the action of the biosynthetic enzymes of Propionibacterium shermanii. The observation that acetaldehyde (rather than acetic acid) is extruded during anaerobic B12 synthesis is in full accord with the structure of factor IV, a new intermediate on the pathway.

References

Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L MombelliD Arigoni
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A R BattersbyA Pfenninger
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A I ScottG Müller

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Citations

Mar 16, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·A I Scott
Aug 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Simon J MooreMartin J Warren
Aug 29, 2006·Journal of Bacteriology·Charles A Roessner, A Ian Scott
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A I ScottG Müller
May 24, 2012·Biochemical Society Transactions·Simon J Moore, Martin J Warren
Oct 23, 1997·Chemistry & Biology·P J SantanderA I Scott
Apr 4, 2020·The Journal of Biological Chemistry·Donald A BryantMartin J Warren
Jul 27, 2005·Biochemical Society Transactions·S FrankM J Warren
Sep 1, 2008·EcoSal Plus·Jorge C Escalante-Semerena, Martin J Warren
Mar 29, 2003·The Journal of Organic Chemistry·A Ian Scott

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