PMID: 2497290Jan 1, 1989Paper

Biosynthetic arginine decarboxylase in phytopathogenic fungi

Life Sciences
A J Khan, S C Minocha

Abstract

It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogenic fungi (Ceratocystis minor and Verticillium dahliae) contain significant levels of ADC activity with very little ODC. The ADC in these fungi has high pH optimum (8.4) and low Km (0.237 mM for C. minor, 0.103 mM for V. dahliae), and is strongly inhibited by alpha-difluoromethylarginine (DFMA), putrescine and spermidine, further showing that this enzyme is probably involved in the biosynthesis of polyamines and not in the catabolism of arginine as in Escherichia coli. The growth of these fungi is strongly inhibited by DFMA while alpha-difluoromethylornithine (DFMO) has little effect.

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Citations

May 4, 2004·Plant Physiology and Biochemistry : PPB·Byung Hak HaKyung Hyun Kim
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·S M BoyleG T Cole
Jul 12, 1995·Annals of the New York Academy of Sciences·G LiD J Reis
Sep 8, 2012·Journal of Amino Acids·Laura Valdés-SantiagoJosé Ruiz-Herrera
Jun 7, 2015·Applied and Environmental Microbiology·Sunil KumarNarayan S Punekar
Mar 12, 2020·Biomolecules·Mervi T HyvönenAlex R Khomutov
Aug 30, 2019·Fungal Genetics and Biology : FG & B·Luis L Pérez-MozquedaErnestina Castro-Longoria

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