PMID: 1203251Dec 17, 1975Paper

Biosynthetic studies on mannolipids and mannoproteins of normal and vitamin A-depleted hamster livers

Biochimica Et Biophysica Acta
L M De LucaR M Barr

Abstract

The incorporation of [1-14C]mannose into hamster liver glycolipids and glycoproteins was studied in normal and vitamin A-depleted hamsters. Severly (25% weight loss) and mildly (no weight loss) deficient animals were compared to vitamin A-fed controls. The incorporation of [14C]mannose into glycolipids and glycoproteins decreased in mild and severe vitamin A deficiency by 63-90% compared to vitamin A-fed animals. These results were essentially the same whether expressed per g of wet liver, per DNA or per protein. The size of the pools of mannose, glucose and galactose and their specific radioactivity in liver were determined by gas-liquid chromatography of the boronates of the hexitols (Eisenberg, Jr, F. (1972) Methods Enzymol. XXVIIIB, 168-178) in normal and vitamin A-deficient conditions. It was found that the amount of free hexoses per g of liver was very similar in normal and vitamin A-deficient conditions. The specific radioactivities for mannose and glucose were greater in vitamin A deficiency, thus excluding the possibility that the observed severe decrease in glycopeptide and glycolipid synthesis is a reflection of a similar decrease in the specific radioactivity of the precursor pools. Quantitation of mannose in glycop...Continue Reading

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Citations

Jun 1, 1992·Glycoconjugate Journal·R TauberW Reutter
Mar 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·B PeriquetJ P Thouvenot
Apr 1, 1982·Journal of the American Academy of Dermatology·L M De Luca
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Nov 30, 1981·Biochemical and Biophysical Research Communications·M MurakamiT Ohgo

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