Biotags Based on Surface-Enhanced Raman Can Be as Bright as Fluorescence Tags

Nano Letters
Alessia PallaoroMartin Moskovits

Abstract

Surface enhanced Raman spectroscopy (SERS) is a powerful analytical technique that has been proposed as a substitute for fluorescence for biological imaging and detection but is not yet commercially utilized. The reason lies primarily in the lower intensity and poor reproducibility of most metal nanoparticle-based tags as compared to their fluorescence-based counterparts. Here, using a technique that scrupulously preserves the same number of dye molecules in both the SERS and fluorescence measurements, we show that SERS-based biotags (SBTs) with highly reproducible optical properties can be nanoengineered such that their brightness is at least equal to that of fluorescence-based tags.

References

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Citations

Apr 11, 2017·Analytical Chemistry·Huiqiao LiuDingbin Liu
Jun 27, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Ali O AltunHyung Gyu Park
Nov 28, 2017·Faraday Discussions·Marc D Porter, Jennifer H Granger
Mar 17, 2017·Annual Review of Analytical Chemistry·Aleem Syed, Emily A Smith
Feb 14, 2021·International Journal of Molecular Sciences·Homan KangYoon-Sik Lee
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
Feb 13, 2020·Nano Letters·Eric Hopmann, Abdulhakem Y Elezzabi
Mar 6, 2018·Journal of the American Chemical Society·Ying ZhangLianhui Wang
Feb 8, 2018·ACS Sensors·Sabrina A CamachoAlexandre G Brolo
Oct 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maria C GomesJoão P C Tomé

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