Biotechnological aspects of the production of the anticancer drug podophyllotoxin

Applied Microbiology and Biotechnology
Sunita FarkyaAshok K Srivastava

Abstract

The natural lignan podophyllotoxin, a dimerized product of two phenylpropanoid moieties which occurs in a few plant species, is a pharmacologically important compound for its anticancer activities. It is used as a precursor for the chemical synthesis of the anticancer drugs etoposide, teniposide and etopophose. The availability of this lignan is becoming increasingly limited because of the scarce occurrence of its natural sources and also because synthetic approaches for its production are still commercially unacceptable. Biotechnological production using cell culture may be considered as an alternative source. Selection of the best performing cell line, its maintenance and stabilization are necessary prerequisites for its production in bioreactors and subsequent scale-up of the cultivation process to the industrial level. Scale-up of growth and product yield depends on a multitude of factors, such as growth medium, physicochemical conditions, seed inoculum, type of reactor and processing conditions. The composition of the growth medium, elicitors and precursors, etc. can markedly influence the production. Optimum levels of parameters that facilitate high growth and product response in cell suspensions of Podophyllum hexandrum ...Continue Reading

Citations

May 10, 2008·Médecine sciences : M/S·Frédéric LamblinEric Lainé
Dec 25, 2012·BMC Complementary and Alternative Medicine·Mengfei LiWei Li
Mar 18, 2008·Journal of Bioscience and Bioengineering·Sunita Farkya, Virendra Swarup Bisaria
Apr 12, 2007·Archives of Pharmacal Research·Yung-Choon YooKyung-Bok Lee
Jun 11, 2005·Biotechnology and Bioengineering·Laurence Lamboursain, Mario Jolicoeur
Sep 8, 2010·Pharmaceutical Biology·Morteza YousefzadiAlireza Ghasempour
Feb 6, 2021·Journal of Complementary & Integrative Medicine·Mohd Afsahul KalamTariq Ahmad Butt
May 1, 2021·Biomolecules·Zinnia ShahBianca Popovici

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