Biotechnological Exploration of Transformed Root Culture for Value-Added Products.

Trends in Biotechnology
Min ShiGuoyin Kai

Abstract

Medicinal plants produce valuable secondary metabolites with anticancer, analgesic, anticholinergic or other activities, but low metabolite levels and limited available tissue restrict metabolite yields. Transformed root cultures, also called hairy roots, provide a feasible approach for producing valuable secondary metabolites. Various strategies have been used to enhance secondary metabolite production in hairy roots, including increasing substrate availability, regulating key biosynthetic genes, multigene engineering, combining genetic engineering and elicitation, using transcription factors (TFs), and introducing new genes. In this review, we focus on recent developments in hairy roots from medicinal plants, techniques to boost production of desired secondary metabolites, and the development of new technologies to study these metabolites. We also discuss recent trends, emerging applications, and future perspectives.

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Citations

Dec 20, 2020·International Journal of Molecular Sciences·Bin ZhangJuane Dong
Apr 4, 2021·International Journal of Molecular Sciences·Raffaella BalestriniElisa Zampieri
Apr 28, 2021·Plant Science : an International Journal of Experimental Plant Biology·Haimin ChenZongsuo Liang
Dec 21, 2020·Trends in Biotechnology·Francisco Javier Molina-HidalgoAlain Goossens

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