PMID: 2933068Sep 1, 1985

Biotin deficiency and susceptibility to fatty liver and kidney syndrome in broiler chicks: reduced 6-phosphofructokinase (EC activity but normal fructose 2,6-bisphosphate content in birds with hepatomegaly

The British Journal of Nutrition
D W BannisterA Lee


In two separate experiments, using different strains, broiler chicks were reared on either a commercial-type chick mash (control) or a fatty liver and kidney syndrome (FLKS)-inducing diet. In Expt a, chicks were killed on day 29 and in Expt b, on day 32. Body-weights and liver weights were measured, and values from those given the control ration used to construct a hepatomegaly index by employing a variant of linear discriminant analysis. Application of the index to FLKS birds revealed a statistically significant bimodal distribution of liver size. The birds with enlarged livers (high index) also possessed metabolic abnormalities in that 6-phosphofructokinase (EC; PFK-1) activity (measured at low substrate concentration) was depressed despite the presence of normal, or even slightly elevated fructose 2,6-bisphosphate concentration. This indicates the presence of an uncharacterized regulatory mechanism for PFK-1 in FLKS-susceptible birds.


Dec 1, 1976·Australian Journal of Biological Sciences·R L HoodJ A Pearson
Sep 1, 1978·The British Journal of Nutrition·C C WhiteheadM E Cleland
Dec 1, 1976·Australian Journal of Biological Sciences·J A PearsonA C Fogerty
Dec 15, 1982·Biochemical and Biophysical Research Communications·T H Claus, S J Pilkis
Sep 15, 1983·The Biochemical Journal·L HueB Jeanrenaud
Dec 1, 1984·Archives of Biochemistry and Biophysics·D A Kruep, G A Dunaway
Dec 1, 1984·Archives of Biochemistry and Biophysics·D A Kruep, G A Dunaway
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E Van Schaftingen, H G Hers
Jul 15, 1982·The Biochemical Journal·H G Hers, E Van Schaftingen
Nov 1, 1982·Acta paediatrica Scandinavica·Y HofvanderS Sjölin
Mar 1, 1981·Acta paediatrica Scandinavica·M F PiccianoR H Deering
Jan 1, 1945·Acta Paediatrica·A WALLGREN

Related Concepts

Metabolic Process, Cellular
Thyroid Hormone Metabolism, Abnormal
Phosphofructokinase-1, Muscle Type
PFKM wt Allele
PFKM gene
Depressed - Symptom
Fructose 2,6-diphosphate
Fatty Liver
CDK2 protein, human

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