Biotin Functionalized Self-Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response

Biotechnology Journal
Muhammed Burak DemircanAyse B Tekinay

Abstract

Biotinylated peptide amphiphile (Biotin-PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant. Antigen attached Biotin-PA nanofibers trigger splenocytes to produce high levels of cytokines (IFN-γ, IL-12, TNF-α, and IL-6) and to exhibit a superior cross-presentation of the antigen. Both Biotin-PA nanofibers and CpG ODN induce a Th-1-biased IgG subclass response; however, delivering the antigen with Biotin-PA nanofibers induce significantly greater production of total IgG and subclasses of IgG compared to delivering the antigen with CpG ODN. Contrary to CpG ODN, Biotin-PA nanofibers also enhance antigen-specific splenocyte proliferation and increase the proportion of the antigen-specific CD8(+) T cells. Given their biodegradability and biocompatibility, Biotin-PA nanofibers have a significant potential in immunoengineering applications as a biomaterial for the delivery of a diverse set of antigens deri...Continue Reading

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Dec 8, 2020·Biotechnology Journal·Mariana B OliveiraJoão F Mano
Feb 2, 2021·Frontiers in Pharmacology·Gillina F G Bezemer, Johan Garssen
May 20, 2021·Acta Biomaterialia·Conor L O'NeillJai S Rudra
Jul 2, 2021·Biomacromolecules·Marta Díaz-CaballeroSalvador Ventura
Jan 16, 2021·ACS Biomaterials Science & Engineering·Jie WangHao Wang

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