PMID: 9164991May 1, 1997Paper

Biotin status assessed longitudinally in pregnant women

The Journal of Nutrition
Donald M MockN I Mock

Abstract

This study assessed biotin nutritional status longitudinally during pregnancy as judged by urinary excretion of biotin and biotin metabolites and by serum concentration of biotin. 3-Hydroxyisovaleric acid excretion was also assessed because increased excretion of that acid reflects decreased tissue activity of the biotin-dependent enzyme, methylcrotonyl-CoA carboxylase. Thirteen women provided untimed urine samples during both early and late pregnancy. Twelve nonpregnant women served as controls. Biotin and metabolites were determined by a combined HPLC/avidin-binding assay. 3-Hydroxyisovaleric acid was determined by gas chromatography/mass spectrophotometry. Significance of changes from early to late pregnancy was tested by paired t test; to compare nonpregnant controls with early and late pregnancy, ANOVA was used. During early pregnancy, biotin excretion was not significantly different than controls; however, 3-hydroxyisovaleric acid excretion was significantly increased relative to controls (P < 0.0001) and was greater than the upper limit of normal in 9 of 13 women. From early to late pregnancy, biotin excretion decreased in 10 of 13 women (P < 0.01); by late pregnancy, biotin excretion was less than normal in six women. D...Continue Reading

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Citations

Jan 30, 2002·The American Journal of Clinical Nutrition·Hamid M Said
Sep 28, 2004·The American Journal of Clinical Nutrition·Wendy M SealeyDonald M Mock
Sep 9, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jack C ReidlingHamid M Said
Dec 1, 2006·American Journal of Physiology. Cell Physiology·Jack C Reidling, Hamid M Said
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Ayumi Taniguchi, Toshiaki Watanabe
May 3, 2008·Congenital Anomalies·Ayumi Taniguchi, Toshiaki Watanabe
Mar 26, 2009·BioFactors·Janos ZempleniYousef I Hassan
Jan 11, 2013·The British Journal of Nutrition·Wei Kay EngJanos Zempleni
Jan 1, 2013·Nutrition and Metabolic Insights·Katsumi ShibataTsutomu Fukuwatari
Oct 17, 2014·The Journal of Nutrition·Donald M Mock
Feb 24, 2016·Scientific Reports·Tzu-Cheng SungChien-Sheng Chen
Oct 12, 1999·The American Journal of Physiology·N S ChatterjeeH M Said
Aug 4, 1998·The American Journal of Physiology·J Zempleni, D M Mock
Jul 14, 2011·The Biochemical Journal·Hamid M Said
Jan 7, 2011·American Journal of Physiology. Renal Physiology·Veedamali S SubramanianHamid M Said
Aug 15, 2014·The Journal of Nutrition·Cydne A PerryMarie A Caudill
Jun 11, 2002·Annual Review of Nutrition·Robert J McMahon
Jul 31, 2003·The Journal of Nutrition·Donald M MockDeborah K Hansen
Mar 13, 1999·The American Journal of Clinical Nutrition·H M Said
Aug 21, 2008·Nutrition Reviews·Janos ZempleniSubhashinee S K Wijeratne
Mar 6, 2010·Congenital Anomalies·Toshiaki WatanabeToru Fukui
Feb 13, 2009·American Journal of Physiology. Cell Physiology·Veedamali S SubramanianHamid M Said
Dec 6, 2008·The Journal of Nutrition·Hamid M Said
Jan 30, 2002·The American Journal of Clinical Nutrition·Donald M MockNell I Mock
Oct 15, 2010·The American Journal of Clinical Nutrition·Shawna L StrattonDonald M Mock
Jan 9, 2008·The British Journal of Nutrition·Mari Watanabe-KamiyamaMichio Komai
Oct 23, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Bianca M PiracciniAntonella Tosti
Aug 10, 2006·The American Journal of Clinical Nutrition·Shawna L StrattonDonald M Mock
Sep 4, 2009·Expert Review of Endocrinology & Metabolism·Janos ZempleniSubhashinee Sk Wijeratne
Jan 13, 2000·Proceedings of the Society for Experimental Biology and Medicine·J Zempleni, D M Mock
Mar 4, 1999·The Journal of Nutrition·D M Mock
Nov 13, 2004·The Journal of Nutritional Biochemistry·J Zempleni, D M Mock
Jul 25, 2000·Journal of Chromatography. a·E LivaniouG P Evangelatos

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