Biotin-streptavidin-guided two-step pretargeting approach using PLGA for molecular ultrasound imaging and chemotherapy for ovarian cancer.

PeerJ
Hang ZhouFang Li

Abstract

Ovarian cancer seriously threatens the lives and health of women, and early diagnosis and treatment are still challenging. Pre-targeting is a promising strategy to improve the treatment efficacy of ovarian cancer and the results of ultrasound imaging. To explore the effects of a pre-targeting strategy using streptavidin (SA) and paclitaxel (PTX)-loaded phase-shifting poly lactic-co-glycolic acid (PLGA) nanoparticles with perfluoro-n-pentane (PTX-PLGA-SA/PFPs) on the treatment and ultrasound imaging of ovarian cancer. PTX-PLGA/PFPs were prepared with a single emulsion (O/W) solvent evaporation method and SA was attached using carbodiimide. The encapsulation efficiency of PTX and the release characteristics were assessed with high performance liquid chromatography. The phase-change characteristics of the PTX-PLGA-SA/PFPs were investigated. The anti-carcinoembryonic antigen (CEA) antibody (Ab) was covalently attached to PTX-PLGA/PFPs via carbodiimide to create PTX-PLGA-Ab/PFPs. The targeting efficiency of the nanoparticles and the viability of ovarian cancer SKOV3 cells were evaluated in each group using a microscope, flow cytometry, and cell counting kit 8 assays. THE PTX-PLGA-SA/PFPs were spheres with a size of 383.0 ± 75.59 nm....Continue Reading

References

Nov 6, 2007·Cancer Biotherapy & Radiopharmaceuticals·Kyung-Ho JungKyung-Han Lee
Dec 7, 2007·International Journal of Pharmaceutics·D KloseJ Siepmann
Nov 13, 2008·British Journal of Cancer·V GonçalvesN Tarrier
Mar 17, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Boitumelo SemeteHulda S Swai
Jan 29, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Birgit MellerJohannes Meller
Jan 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susana Banerjee, Stanley B Kaye
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J LopezS B Kaye
Jan 2, 2014·Maturitas·Bernd C Schmid, Martin K Oehler
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fatemeh Sadat Tabatabaei MirakabadSang Woo Joo
Apr 9, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Paul A MountfordMark A Borden
Jun 29, 2016·European Journal of Histochemistry : EJH·M CostanzoM Malatesta
Dec 17, 2019·Molecular Pharmaceutics·Sudath HapuarachchigeDmitri Artemov
Feb 14, 2020·Advances in Radiation Oncology·Gregory C StachelekLawrence Kleinberg
Feb 27, 2020·International Journal of Molecular Sciences·Cinzia ImbertiPhilip J Blower
Apr 8, 2020·Journal of Biomedical Nanotechnology·Paola AllavenaAkihiro Maeda
Aug 15, 2020·Frontiers in Oncology·Sudath Hapuarachchige, Dmitri Artemov

❮ Previous
Next ❯

Software Mentioned

DFY
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.