Abstract
β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups, i.e., cyanobacteria, diatoms, and dinoflagellates. Bioaccumulation of BMAA in invertebrate and vertebrate organisms has also been registered around the globe. In the Baltic Sea, BMAA has been detected in several commercial fish species, raising the question of the bioaccumulation of BMAA in Swedish limnic systems. Here we find the presence of BMAA in water samples from Lake Finjasjön and identify its bioaccumulation patterns in both plankti-benthivorous and piscivorous fish, according to fish species, total weight, gender, and season of collection. For the first time, a large number of fish individuals were used in order to draw conclusions on BMAA bioaccumulation in a closed ecological community based on a statistical approach. We may, therefore, conclude that feeding patterns (plankti-benthivorous) and increased age of fish may lead to a higher tissue concentration of BMAA.
References
May 1, 1991·Neurology·P S SpencerA C Ludolph
Aug 1, 1987·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P S Spencer
Jul 5, 1974·Journal of Molecular Biology·G Robillard, R G Shulman
Jul 5, 1974·Journal of Molecular Biology·G Robillard, R G Shulman
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxSusan J Murch
Sep 10, 2004·Acta Neurologica Scandinavica·S J MurchO W Sacks
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Paul Alan CoxBirgitta Bergman
Jun 13, 2006·Experimental Neurology·Shyam D RaoJohn H Weiss
Aug 30, 2006·Ecology·Anders Persson, Marika Stenberg
Nov 14, 2006·Neurobiology of Disease·Doug LobnerRobert W Peoples
Nov 17, 2006·Molecular Phylogenetics and Evolution·Maurice Kottelat
Nov 23, 2006·FEMS Microbiology Ecology·Jenny DegerholmErik Söderbäck
Feb 2, 2008·Environmental Microbiology·James S MetcalfGeoffrey A Codd
Jun 10, 2008·Ecotoxicology and Environmental Safety·M Esterhuizen, T G Downing
Mar 4, 2009·Acta Neurologica Scandinavica·J PabloD C Mash
Oct 14, 2009·Toxicon : Official Journal of the International Society on Toxinology·Aifeng LiZhenyu Wang
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Elisabeth J FaassenMiquel Lürling
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Derek CraigheadMijiddorj Batmunkh
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Paul Alan CoxWalter G Bradley
Nov 26, 2009·Neuroreport·Xiao Qian LiuDoug Lobner
Dec 22, 2009·The Analyst·Zdenek SpácilBirgitta Bergman
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sara JonassonBirgitta Bergman
Jun 19, 2010·Journal of Fish Biology·L NurminenJ Horppila
Nov 9, 2010·Harmful Algae·Larry E BrandDeborah C Mash
Feb 9, 2012·Neuroreport·Travis RushDoug Lobner
Mar 14, 2012·Marine Drugs·Kiyo MondoDeborah C Mash
Mar 17, 2012·The Analyst·Steven A Cohen
May 10, 2012·PloS One·Elisabeth J FaassenMiquel Lürling
Nov 28, 2012·Analytical and Bioanalytical Chemistry·Liying JiangLeopold L Ilag
Sep 24, 2013·The Science of the Total Environment·Yiying JiaoLiuyan Yang
Jun 1, 1987·Fish Physiology and Biochemistry·B Lal, T P Singh
Jan 7, 2014·PloS One·Liying JiangUlla Rasmussen
Mar 26, 2014·Toxins·Elisabeth J Faassen
Apr 22, 2014·Aquatic Toxicology·Sandra LageSara Jonasson Rydberg
Citations
Aug 26, 2015·Environmental Science and Pollution Research International·Sandra LageSara Rydberg
Nov 10, 2016·Marine Drugs·Aifeng LiMeihui Li
Jan 23, 2017·Archives of Toxicology·Franca M BurattiEnzo Funari
Apr 15, 2017·Environmental Toxicology and Chemistry·Aloysio da S Ferrão-FilhoEduardo Mendes da Silva
Jan 13, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Valeska Contardo-JaraStephan Pflugmacher
Dec 28, 2017·Toxins·Laura Louise Scott, Timothy Grant Downing
Feb 15, 2018·Toxins·Emilie LanceRonel Biré
Sep 8, 2017·Neurotoxicity Research·Anthony LaugerayGilles J Guillemin
Mar 13, 2018·Journal of Pineal Research·Paula PierozanOskar Karlsson
Oct 27, 2015·Scientific Reports·Oskar KarlssonEva B Brittebo
Jan 25, 2020·Toxins·Alexandra LepoutreEmilie Lance
Jun 10, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·N ChernoffW M Winnik
Mar 9, 2018·Frontiers in Plant Science·Sabine HiltCarl D Sayer
Sep 5, 2019·Toxins·Jake P VioliKenneth J Rodgers
Jul 20, 2019·Scientific Reports·Nadezda ZgunaElena Gorokhova
May 6, 2017·Neurotoxicity Research·Sandra Anne Banack, Susan J Murch
Jun 19, 2019·Cell Death & Disease·Paula Pierozan, Oskar Karlsson
May 5, 2017·Neurotoxicity Research·Laura Louise ScottTimothy Grant Downing
Aug 5, 2019·Neurotoxicity Research·Rachael A Dunlop, Gilles J Guillemin
Dec 14, 2018·Toxins·Megan Brooke-JonesHeinrich Dircksen
May 10, 2020·Marine Drugs·Sea-Yong Kim, Sara Rydberg
Jan 12, 2020·Environmental Pollution·A LepoutreE Lance
Nov 1, 2020·Journal of Hazardous Materials·Chao WangAifeng Li
Nov 18, 2019·Toxicon : Official Journal of the International Society on Toxinology·Shuqin WangAifeng Li
Jun 20, 2018·Toxicon : Official Journal of the International Society on Toxinology·Laura L ScottTim Downing
Aug 28, 2021·International Journal of Molecular Sciences·Paola SiniClaudia Crosio