Biotransformation of α-bromoacetophenones by the marine fungus Aspergillus sydowii.

Marine Biotechnology
Lenilson C RochaAndré Luiz Meleiro Porto

Abstract

The biotransformation reactions of α-bromoacetophenone (1), p-bromo-α-bromoacetophenone (2), and p-nitro-α-bromoacetophenone (3) by whole cells of the marine fungus Aspergillus sydowii Ce19 have been investigated. Fungal cells that had been grown in artificial sea water medium containing a high concentration of chloride ions (1.20 M) catalysed the biotransformation of 1 to 2-bromo-1-phenylethanol 4 (56%), together with the α-chlorohydrin 7 (9%), 1-phenylethan-1,2-diol 9 (26%), acetophenone 10 (4%) and phenylethanol 11 (5%) identified by GC-MS analysis. In addition, it was observed that the enzymatic reaction was accompanied by the spontaneous debromination of 1 to yield α-chloroacetophenone 5 (9%) and α-hydroxyacetophenone 6 (18%) identified by GC-FID analysis. When 2 and 3 were employed as substrates, various biotransformation products were detected but the formation of halohydrins was not observed. It is concluded that marine fungus A. sydowii Ce19 presents potential for the biotransformations of bromoacetophenone derivatives.

References

Aug 9, 2001·Journal of Industrial Microbiology & Biotechnology·A GoswamiR N Patel
Sep 3, 2005·Revista Do Instituto De Medicina Tropical De São Paulo·Divani Maria Capuano, Gutemberg de Melo Rocha
May 9, 2007·Applied Microbiology and Biotechnology·Katja GoldbergAndreas Liese
Jun 6, 2009·Biotechnology Letters·Lenilson C RochaAndré L M Porto

❮ Previous
Next ❯

Citations

Jun 16, 2010·Marine Biotechnology·Mariana Provedel MartinsAndré Luiz Meleiro Porto
Jul 14, 2012·Marine Biotechnology·Julieta Rangel de OliveiraAndré Luiz Meleiro Porto
Dec 14, 2011·Marine Biotechnology·Lenilson C RochaAndré L M Porto
Jun 2, 2012·Marine Biotechnology·Lenilson C RochaAndré L M Porto
Dec 9, 2014·International Journal of Molecular Sciences·Tomasz JaneczkoEdyta Kostrzewa-Susłow
Aug 15, 2015·Marine Biotechnology·Lenilson C RochaAndré L M Porto
May 26, 2015·Annals of Microbiology·Tomasz JaneczkoEdyta Kostrzewa-Susłow
Jan 12, 2017·Applied Microbiology and Biotechnology·Yu-Guo ZhengZhi-Qiang Liu
Dec 22, 2017·Applied Microbiology and Biotechnology·Hui LiuBi-Shuang Chen
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui LiuBi-Shuang Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.