Biotransformation of imperatorin by Aspergillus flavus

Journal of Natural Products
Wen-Yuh TengChien-Chih Chen

Abstract

Imperatorin (1) was metabolized by Aspergillus flavus, in growth media, to give five metabolites. On the basis of their physical data, the structures of the five metabolites were elucidated as xanthotoxol (2), E-trichoclin (3), Z-trichoclin (4), E-imperatorin acid (5), and Z-imperatorin acid (6); among these, 4, 5, and 6 were characterized as new coumarins. The five metabolites 2-6 were tested for anti-hepatitis B virus activity in vitro and found to be less active than the parent compound 1.

References

Dec 1, 1989·Photochemistry and Photobiology·D Averbeck

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Citations

Jan 10, 2008·Applied Microbiology and Biotechnology·Kyung MyungJan A Narciso
Jun 4, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Haoli HuoLantong Zhang
Feb 1, 2017·Journal of Asian Natural Products Research·Xiu-Lan XinXiang-Ge Tian
Sep 20, 2018·Journal of Agricultural and Food Chemistry·Mangala Gowri PonnapalliPuran Singh Sijwali
Sep 15, 2021·Natural Product Research·Hui-Chi HuangYueh-Hsiung Kuo

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