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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

Chemical Research in Toxicology

Jan 1, 1991

J Greg SlatterThomas A Baillie

PMID: 1782345

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Abstract

S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry (LC-MS) in the urine of rats dosed intraperitoneally with methyl isocyanate (MIC; 45.2 mumol). The corresponding cysteine conjugate, h...read more

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Cysteine
Chemicals
Conjugation
Metabolic Detoxication, Drug
Biochemical Pathway
Acetylcysteine
Portion of Urine
Cysteine Hydrochloride
S-(N-methylcarbamoyl)cysteine
Acetylcysteine, (DL)-Isomer
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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

Chemical Research in Toxicology

Jan 1, 1991

J Greg SlatterThomas A Baillie

PMID: 1782345

DOI:

Abstract

S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry (LC-MS) in the urine of rats dosed intraperitoneally with methyl isocyanate (MIC; 45.2 mumol). The corresponding cysteine conjugate, h...read more

Mentioned in this Paper

Cysteine
Chemicals
Conjugation
Metabolic Detoxication, Drug
Biochemical Pathway

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Paper Details
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  • Citations38
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  • Citations38
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