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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

Chemical Research in Toxicology

Mar 1, 1991

J G SlatterT A Baillie

PMID: 1782345

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Abstract

S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry (LC-MS) in the urine of rats dosed intraperitoneally with methyl isocyanate (MIC; 45.2 mumol). The corresponding cysteine conjugate, h...read more

Mentioned in this Paper

Isocyanates
Metabolic Process, Cellular
Biochemical Pathway
Urine
Conjugation
Protein Methylation
Carbamates
Thioester
S-(N-methylcarbamoyl)cysteine
August Rats
Paper Details
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Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities

Chemical Research in Toxicology

Mar 1, 1991

J G SlatterT A Baillie

PMID: 1782345

DOI:

Abstract

S-(N-Methylcarbamoyl)-N-acetylcysteine (AMCC), a chemically labile mercapturic acid conjugate, was identified by liquid chromatography-mass spectrometry (LC-MS) in the urine of rats dosed intraperitoneally with methyl isocyanate (MIC; 45.2 mumol). The corresponding cysteine conjugate, h...read more

Mentioned in this Paper

Isocyanates
Metabolic Process, Cellular
Biochemical Pathway
Urine
Conjugation
Protein Methylation
Carbamates
Thioester
S-(N-methylcarbamoyl)cysteine
August Rats

Feeds With Similar Papers

MS: Therapies

The feed focuses on therapeutic interventions used to treat Multiple Sclerosis.

Multiple Sclerosis

Multiple Sclerosis is a demyelinating autoimmune disease of the CNS, resulting in symptoms including optic neuritis and motor weakness. Discover the latest research on Multiple Sclerosis here.

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Biochemical and Biophysical Research Communications

S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate

Biochemical and Biophysical Research CommunicationsJanuary 15, 1990
P G PearsonT A Baillie
Paper Details
References
  • References
  • Citations45
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations45
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