Biotransformation of organic nitrates and vascular smooth muscle cell function

Trends in Pharmacological Sciences
Brian M BennettW C Simon


The organic nitrates are interesting examples of drugs that undergo biotransformation at their site of action to generate the active form of the drug. Furthermore, tolerance to the vasodilator effects of organic nitrates is associated with impairment of this metabolic activation process. Despite considerable research effort, the intracellular processes and the chemical reaction pathways by which organic nitrates are converted to their active form are still unresolved. This review by Brian Bennett and colleagues summarizes the characteristics of organic-nitrate biotransformation in vascular smooth muscle, the difficulties encountered when assessing this biotransformation, and the evidence for the role of two identified vascular biotransformation systems (glutathione-S-transferases and the cytochrome P450 system) in the metabolic activation of organic nitrates.


Dec 18, 1992·Science·Jonathan S StamlerJ Loscalzo
May 28, 1992·Biochemical Pharmacology·D T Lau, L Z Benet
Oct 15, 1991·Biochemical and Biophysical Research Communications·M Feelisch, M Kelm
Sep 1, 1991·Canadian Journal of Physiology and Pharmacology·Brian M BennettR Baur
Dec 1, 1990·Canadian Journal of Physiology and Pharmacology·B J McDonald, Brian M Bennett
Feb 1, 1989·Archives of Biochemistry and Biophysics·D R DuttonA Parkinson
Jun 1, 1989·Biochemical Pharmacology·R A YeatesM Leitold
Sep 29, 1989·Biochemical and Biophysical Research Communications·D ServentM Lenfant
Nov 1, 1989·Canadian Journal of Physiology and Pharmacology·D H StewartBrian M Bennett
May 1, 1988·Archives of Biochemistry and Biophysics·M Murray
Feb 1, 1993·Canadian Journal of Physiology and Pharmacology·R NigamBrian M Bennett
Jan 7, 1993·Biochemical Pharmacology·B J McDonald, Brian M Bennett
Apr 1, 1993·Clinical Pharmacology and Therapeutics·W E HaefeliT F Blaschke
Feb 1, 1993·Journal of Pharmacological and Toxicological Methods·W C SimonBrian M Bennett


Feb 21, 2004·European Journal of Pharmacology·I S De la LandeJ D Horowitz
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Daniela GiustariniRanieri Rossi
Oct 31, 1996·European Journal of Pharmacology·I S De la LandeJ D Horowitz
Dec 27, 1996·European Journal of Pharmacology·I S De la LandeJ D Horowitz
Dec 1, 2001·Free Radical Biology & Medicine·Yukiko MinamiyamaY Funae
Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·James N ReynoldsGregory R J Thatcher
Aug 7, 1998·Journal of Pharmacological and Toxicological Methods·J PatariczaJ G Papp
Oct 12, 1999·British Journal of Pharmacology·R WalterW H Reinhart
Oct 23, 2002·Clinical and Experimental Pharmacology & Physiology·Toshihiro MatsuzakiMatao Sakanashi
May 3, 2008·The Journal of Biological Chemistry·Matteo BerettaBernd Mayer
Dec 26, 2001·Journal of the National Cancer Institute·N E MatthewsCharles H Graham
Dec 24, 1997·The Journal of Pharmacy and Pharmacology·U HodoglugilH Zengil
Feb 11, 1995·BMJ : British Medical Journal·A Breckenridge
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Ho-Leung Fung
Apr 7, 2012·Critical Care Research and Practice·Bobby NossamanPhilip Kadowitz
Apr 3, 2012·Chemical & Pharmaceutical Bulletin·Namdev BorhadeApparao Satyam
Feb 27, 2003·Clinical Pharmacokinetics·Satoru Hashimoto, Atsuko Kobayashi
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhiqiang ChenJonathan S Stamler
Jan 5, 2002·Expert Opinion on Investigational Drugs·R G TiltonR A Dixon
Sep 19, 2003·Archives of Biochemistry and Biophysics·Ayesha RahmanMohammad Athar
Sep 29, 2004·Free Radical Biology & Medicine·Gregory R J ThatcherVioleta Toader
Oct 24, 2006·Trends in Cardiovascular Medicine·Zhiqiang Chen, Jonathan S Stamler
Oct 16, 2013·Nitric Oxide : Biology and Chemistry·Shunxin LinHo-Leung Fung
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Lynne-Marie PostovitCharles H Graham
Apr 12, 2003·Redox Report : Communications in Free Radical Research·Yukiko MinamiyamaShigeru Okada
Apr 4, 2008·Clinical Physiology and Functional Imaging·Magnus PeterssonPeter Friberg
May 9, 2002·Expert Opinion on Investigational Drugs·Ian L Megson, David J Webb
Dec 3, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wen WuAnne Sapin-Minet
Oct 6, 2000·Nitric Oxide : Biology and Chemistry·H C Birnboim, H Privora

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.