Biotransformation of tetrahydro-alpha-santonins by Absidia coerulea

Natural Product Research
Lin Yang, Jungui Dai

Abstract

The fungus, Absidia coerulea was employed to bioconvert tetrahydro-alpha-santonins, 1,2,4alpha,5alpha-tetrahydro-alpha-santonin (1), and its 4-epimer (2), from which 10 products (3-12) were obtained. Furthermore, their structures were determined, based on their chemical and spectroscopic data analyses. Among them, 3-5, 7, 9, 11 and 12 were observed to be seven new compounds. The reactions mainly involved in these bio-process included hydroxylation(s) (C-4, C-11, and C-1), reduction (C-3 ketone to alcohol).

References

Aug 9, 2005·Biotechnology Letters·Lin YangMasayoshi Ando
Jul 26, 2006·Journal of Asian Natural Products Research·L YangM Ando

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Citations

Jun 5, 2013·Indian Journal of Microbiology·Busi SiddhardhaS Prabhakar
Aug 21, 2009·Natural Product Reports·Braulio M Fraga
Mar 31, 2021·Journal of Asian Natural Products Research·Nurul Iman Aminudin Zainal Abidin
Jun 11, 2021·Archives of Microbiology·Jonathan Messias de SouzaAna Helena Januário

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Methods Mentioned

BETA
NMR

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