Biparental alleles of HLA-G are co-dominantly expressed in the placenta

The Japanese Journal of Human Genetics
K HashimotoY Murata

Abstract

HLA-G is the only major histocompatibility complex molecule expressed in the human placenta and thus has been considered to be necessary for maintenance of pregnancy. We investigated whether HLA-G expression is regulated in a parent-of-origin allele-specific manner. Of six first trimester and three third trimester placentas, three first trimester and two third trimester placentas showed heterozygosity at the PstI polymorphic site in the 3'-untraslated region. Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed biallelic expression of HLA-G in all the informative cases, indicating that HLA-G is not imprinted during the gestational period, at least at the transcriptional level. As HLA-G has been postulated to be polymorphic not only at the DNA sequence level but also at the peptide level, co-dominant expression of the gene suggests that each parental allele is involved in the allogenic response during pregnancy.

References

Oct 1, 1992·Current Opinion in Immunology·J S Hunt
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Citations

Jun 23, 1999·American Journal of Reproductive Immunology : AJRI·T V Hviid, N Morling
Dec 1, 2020·Journal of Reproductive Immunology·Daniel P JacobsenAnne Cathrine Staff

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