Biparous: a novel bHLH gene expressed in neuronal and glial precursors in Drosophila

Developmental Biology
A BushM Cole

Abstract

Genetic studies have uncovered many genes that are involved in the first steps of neuronal development in Drosophila. Less is known about the intermediate steps during which individual precursor cells follow either the neuronal pathway or the glial pathway. We report the identification of a novel bHLH gene, biparous, expressed in neuronal and glial precursors in Drosophila. Unlike most bHLH genes, biparous expression continues to the final stages of neurogenesis in the embryo. Expression of biparous is not observed in end stage postmitotic neurons and precedes the expression of repo, a gene activated in later stages of glial differentiation. The bHLH domain is sufficiently different from previously described bHLH domains to imply a novel function.

Citations

Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·A W MooreY N Jan
Dec 25, 2004·Developmental Biology·Alexander KuzinWard F Odenwald
Apr 16, 2004·Development·Xiao-Jiang QuanBassem A Hassan
Dec 10, 1999·Experimental Cell Research·F Guillemot
Sep 10, 2002·Developmental Biology·Jennifer BonnerTimothy O'Connor
Jan 17, 2015·Genes & Development·Francesca FroldiLouise Y Cheng

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