Abstract
The effects of the histamine precursor, L-histidine, were examined in the rat kindling model of epilepsy. The intraperitoneal (i.p.) administration of 800 mg/kg L-histidine significantly prolonged the latency to the onset of bilateral forelimb clonus of previously kindled seizures from the amygdala (AM), with no significant effect observed in the behavioral seizure stage or afterdischarge duration. In contrast, daily administration of L-histidine at the same dose prior to each electrical stimulation to the AM significantly facilitated both behavioral and electrographic seizure development of kindling. The present results indicate that although L-histidine can suppress secondary generalization of AM-kindled seizures, it possesses a facilitatory effect on the acquisition of kindling epileptogenesis, suggesting a biphasic action of histamine in kindling.
References
Jan 1, 1978·American Journal of Diseases of Children·J F Schwartz, J H Patterson
Sep 1, 1976·The Journal of Physiology·W G Clark, H R Cumby
Jul 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·H YokoyamaT Watanabe
Nov 1, 1990·Electroencephalography and Clinical Neurophysiology·M SatoD C McIntyre
Sep 1, 1991·Trends in Neurosciences·H WadaT Watanabe
Nov 1, 1991·Epilepsy Research·R ScherklH H Frey
Aug 1, 1986·Neuropharmacology·L Tuomisto, U Tacke
Jan 1, 1988·Experimental Brain Research·G KostopoulosH L Haas
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Sep 8, 1987·Brain Research·T Sutula, O Steward
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Feb 1, 1981·Electroencephalography and Clinical Neurophysiology·S L PetersonL S Gordon
Feb 1, 1995·Neuropharmacology·R E BrownK G Reymann
Jan 1, 1993·Psychopharmacology·H YokoyamaT Watanabe
Jan 23, 1993·Lancet·K IinumaM Itoh
Nov 1, 1993·Neuron·V S VorobjevH L Haas
Jul 2, 1993·Science·J M Bekkers
Feb 3, 1951·Journal of the American Medical Association·J B WYNGAARDEN, M H SEEVERS
Citations
Dec 9, 2003·European Journal of Pharmacology·Lisan ZhangHenk Timmerman
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Mariusz SwiaderStanisław J Czuczwar
Oct 20, 2001·Behavioural Brain Research·L TuomistoA Lecklin
Jun 23, 2000·Epilepsy Research·M YoshidaN Tsuru
May 31, 2001·Epilepsia·C ToberR Bartsch
Jun 7, 2014·Pharmacological Reports : PR·Mariusz J Świąder, Stanisław J Czuczwar
Mar 17, 2007·Brain Research·Lyudmila V VinogradovaLeena Tuomisto
Jan 11, 2007·Journal of Neurochemistry·Gyorgy BagdyRita Jakus
Jul 5, 2012·British Journal of Pharmacology·M BhowmikD Vohora
Feb 26, 2005·Neuroscience·X JiangH Li
Aug 30, 2005·Neuroscience·C-L JinZ Chen
Feb 27, 2016·Epilepsia·Ivette Bañuelos-CabreraLuisa Rocha
Mar 7, 2006·Neuroscience Letters·Xiao-hua WuZhong Chen
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
May 20, 2020·Nutrients·Joanna MoroDalila Azzout-Marniche
Feb 23, 2012·Human & Experimental Toxicology·S JainK K Sharma
Jul 13, 2018·ACS Chemical Neuroscience·Alexander G ZestosRobert T Kennedy
Oct 3, 2021·British Journal of Pharmacology·Lin YangZhong Chen