PMID: 8938266Feb 9, 1996Paper

Biphasic action of the histamine precursor L-histidine in the rat kindling model of epilepsy

Neuroscience Letters
Y WadaY Koshino

Abstract

The effects of the histamine precursor, L-histidine, were examined in the rat kindling model of epilepsy. The intraperitoneal (i.p.) administration of 800 mg/kg L-histidine significantly prolonged the latency to the onset of bilateral forelimb clonus of previously kindled seizures from the amygdala (AM), with no significant effect observed in the behavioral seizure stage or afterdischarge duration. In contrast, daily administration of L-histidine at the same dose prior to each electrical stimulation to the AM significantly facilitated both behavioral and electrographic seizure development of kindling. The present results indicate that although L-histidine can suppress secondary generalization of AM-kindled seizures, it possesses a facilitatory effect on the acquisition of kindling epileptogenesis, suggesting a biphasic action of histamine in kindling.

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Citations

Dec 9, 2003·European Journal of Pharmacology·Lisan ZhangHenk Timmerman
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Mariusz SwiaderStanisław J Czuczwar
Oct 20, 2001·Behavioural Brain Research·L TuomistoA Lecklin
Jun 7, 2014·Pharmacological Reports : PR·Mariusz J Świąder, Stanisław J Czuczwar
Mar 17, 2007·Brain Research·Lyudmila V VinogradovaLeena Tuomisto
Jan 11, 2007·Journal of Neurochemistry·Gyorgy BagdyRita Jakus
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Feb 23, 2012·Human & Experimental Toxicology·S JainK K Sharma
Jul 13, 2018·ACS Chemical Neuroscience·Alexander G ZestosRobert T Kennedy
Oct 3, 2021·British Journal of Pharmacology·Lin YangZhong Chen

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