Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure

American Journal of Physiology. Heart and Circulatory Physiology
Gary L AistrupJ Andrew Wasserstrom

Abstract

Although the negative inotropic effects of both acute and chronic ethanol (EtOH) exposure are well known, little is known concerning the acute-to-chronic transition of such effects. In this study, our objective was to address this question by detailing the effects that acute EtOH exposure induces on cellular excitation-contraction (EC) coupling and, subsequently, comparing whether and how such changes translate to the early chronic EtOH condition in a rat model known to develop alcohol-induced cardiomyopathy. Acute EtOH exposure, as formerly reported, indeed induced dose-dependent negative inotropic changes in cellular EC coupling, manifest as reductions in cell shortening, Ca2+ transient amplitude, Ca2+ decay rate, and sarcoplasmic reticulum Ca2+ content of isolated rat ventricular cardiac myocytes. Supplementary to this, we found Ca2+ spark character not to be significantly affected by acute EtOH exposure. In contrast, the results obtained from cardiac myocytes isolated from rats fed a diet containing approximately 9% (vol/vol) EtOH for 1 mo revealed changes in these parameters reflecting positive inotropy, whereas at 3 mo, these parameters again reflected negative inotropy similar but not identical to that induced by acute E...Continue Reading

References

Nov 1, 1976·European Journal of Pharmacology·M A Rossi, J S Oliveira
Sep 1, 1991·Journal of Studies on Alcohol·J AdachiH Imamichi
Jan 1, 1991·European Journal of Clinical Pharmacology·C StrömbergM Kupari
Sep 1, 1990·Journal of Molecular and Cellular Cardiology·K G Mongo, G Vassort
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J H Johnson, B P Crider
Jan 1, 1985·The American Journal of the Medical Sciences·J D BlachleyJ P Knochel
Jun 1, 1989·Journal of Molecular and Cellular Cardiology·A P ThomasE Rubin
Sep 1, 1989·The American Journal of Physiology·Q LiB T Stokes
Feb 16, 1989·The New England Journal of Medicine·A Urbano-MarquezE Rubin
May 1, 1988·Medical Toxicology and Adverse Drug Experience·B AdinoffM Linnoila
Dec 1, 1986·Drug and Alcohol Dependence·R H JohnsonD G Lambie
Nov 1, 1969·American Heart Journal·D P RiffJ T Doyle
May 29, 1970·Science·E Majchrowicz, J H Mendelson
May 1, 1984·The American Journal of Physiology·E R FergusonJ P Knochel
Mar 1, 1981·The American Journal of Cardiology·E C MathewsS E Epstein
Sep 1, 1984·Archives of Biochemistry and Biophysics·S T OhnishiE Rubin
Jan 13, 1995·European Journal of Pharmacology·Y HabuchiM Yoshimura
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·A P ThomasE Rubin
Feb 1, 1997·Journal of Molecular and Cellular Cardiology·R A Haworth, A V Biggs
Sep 3, 1998·Alcoholism, Clinical and Experimental Research·M J EckardtB Tabakoff
Sep 30, 1998·Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism·H S Friedman
Feb 9, 1999·Novartis Foundation Symposium·M Kupari, P Koskinen
Apr 27, 2000·The American Journal of Cardiology·A GavazziM Porcu
May 12, 2000·Journal of the American College of Cardiology·A M LazarevićA D Popović
Feb 7, 2001·Circulation·I J GoldbergUNKNOWN Nutrition Committee, Council on Epidemiology and Prevention, and Council on Cardiovascular Nursing of the American Heart Ass
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Silvia GuatimosimW J Lederer
Dec 14, 2002·Basic Research in Cardiology·Steven O Marx, Andrew R Marks
Sep 25, 2003·Metabolism: Clinical and Experimental·Kay OhlendieckVictor R Preedy

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Citations

Nov 10, 2011·Clinical and Experimental Pharmacology & Physiology·Ethan J AndersonMonte S Willis
Jun 15, 2011·Pharmacology & Therapeutics·Yingmei Zhang, Jun Ren
Apr 2, 2009·European Journal of Heart Failure·Irma LaonigroEmanuele Altomare
May 19, 2010·Alcoholism, Clinical and Experimental Research·Rachel L FogleThomas C Vary
Jun 26, 2014·Alcoholism, Clinical and Experimental Research·Nsini A UmohGeorges E Haddad
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Jun Ren, Loren E Wold
Mar 1, 2018·Frontiers in Pharmacology·Adam ObadSima T Tarzami
Dec 20, 2007·Journal of Cardiovascular Pharmacology·Deepak KhannaMitchell S Finkel
Aug 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Joël de LeirisFrançois Boucher

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