Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence

Journal of Clinical Medicine
Jadwiga Jodynis-Liebert, Małgorzata Kujawska

Abstract

Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed biphasic dose-response and are considered to be hormetic compounds, i.e., they induce biologically opposite effects at different doses. In numerous articles the hormetic nature of phytochemicals is declared, however, no experimental evidence is provided. Our aim was to present the overview of the reports in which phytochemical-induced biphasic dose-response is experimentally proven. Hence, we included in the current review only articles in which the reversal of response between low and high doses/concentrations of phytochemicals for a single endpoint was documented. The majority of data on biphasic dose-response have been found for phytoestrogens; other reports described these types of effects for resveratrol, sulforaphane, and natural compounds from various chemical classes such as isoquinoline alkaloid berberine, polyacetylenes falcarinol and falcarindiol, prenylated pterocarpan glyceollin1, naphthoquinones plumbagin and naphazarin, and panaxatriol saponins. The prevailing part of the studies presented in the current review was performed on cell cultures. The most common endpoint tested was a proliferation of tumor and non-cancerous cells. Very fe...Continue Reading

References

Feb 1, 1996·Carcinogenesis·T T WangJ M Phang
Nov 5, 1997·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·U LutzW K Lutz
Dec 16, 1998·The American Journal of Clinical Nutrition·K D Setchell
Jan 16, 1999·Molecular Reproduction and Development·J T HsuC Ying
Apr 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·R A Ribeiro, G Rodríguez de Lores Arnaiz
Oct 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S TamirJ Vaya
Jul 10, 2002·Human & Experimental Toxicology·E J Calabrese, L A Baldwin
Aug 30, 2002·Reproduction, Nutrition, Development·Chingwen YingLu-Kai Wang
Nov 8, 2002·The Journal of Biological Chemistry·Zhi-Chao DangClemens W G M Löwik
Feb 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Marcello MaggioliniSebastiano Amdò
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·ZhiChao Dang, Clemens W G M Löwik
Aug 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J M GuoQ Liu
Aug 31, 2004·The Journal of Nutrition·Steven J T Jackson, Keith W Singletary
Oct 6, 2005·Environmental Health Perspectives·Kristina A ThayerJames Huff
Mar 1, 2006·International Journal of Cancer. Journal International Du Cancer·Jane L LimerValerie Speirs
Jun 8, 2006·Archives of Pharmacal Research·Seung Min OhKyu Hyuck Chung
Aug 4, 2006·European Journal of Clinical Nutrition·D P Hayes
Sep 27, 2006·Trends in Neurosciences·Mark P Mattson, Aiwu Cheng
Feb 1, 2007·Journal of Agricultural and Food Chemistry·Jette F YoungCharles S Bestwick
Feb 17, 2007·Journal of Ethnopharmacology·Y R LiuJ Weng
Jul 29, 2008·Journal of Lipid Research·Hyoung-Woo Bai, Bao Ting Zhu
Oct 11, 2008·Dose-response : a Publication of International Hormesis Society·Jette F YoungNiels Oksbjerg
Nov 10, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hyoung-Woo Bai, Bao Ting Zhu
May 8, 2010·International Journal of Toxicology·Eric L KendigScott M Belcher
Sep 21, 2010·Clinical and Molecular Allergy : CMA·Salvatore ChirumboloPaolo Bellavite
Dec 1, 2010·Human & Experimental Toxicology·Edward J CalabreseVittorio Calabrese
Dec 1, 2010·Human & Experimental Toxicology·Francine Z Marques, Brian J Morris
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Subhendu MukherjeeDipak K Das

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
chromosomal aberration

Software Mentioned

Google Scholar

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Lippincott Health Promotion Letter
M Philpotts
International Journal of Molecular Sciences
Hara Kang
BioMed Research International
Poyil PratheeshkumarKodappully Sivaraman Siveen
© 2021 Meta ULC. All rights reserved