PMID: 6104954Mar 15, 1980Paper

Biphasic effect of acute ethanol administration on rat liver tyrosine-2-oxoglutarate aminotransferase activity

The Biochemical Journal
A A BadawyM Evans

Abstract

1. Acute ethanol administration causes a biphasic change in rat liver tyrosine aminotransferase activity. 2. The initial decrease is significant with a 200 mg/kg dose of ethanol, is prevented by adrenoceptor-blocking agnets and by reserpine, but not by inhibitors of ethanol metabolism, and exhibits many of the characteristics of the inhibition caused by noradrenaline. 3. The subsequent enhancement of the enzyme activity by ethanol is not associated with stabilization of the enzyme, but is sensitive to actinomycin D and cycloheximide. 4. It is suggested that the initial decrease in aminotransferase activity is caused by the release of catecholamines, whereas the subsequent enhancement may be related to the release of glucocorticoids.

Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·A A BadawyM Evans
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·H RouachR Nordmann
Sep 30, 1988·Biochemical and Biophysical Research Communications·T M DonohueR K Zetterman

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